Atorvastatin Impurity 61 CAS 405-99-2
| CAS No. | 405-99-2 |
| Molecular Formula | C8H7F |
| Molecular Weight | 122.14 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Atorvastatin Impurity 61 (CAS 405-99-2) is a certified pharmaceutical impurity reference standard with the molecular formula C8H7F and a molecular weight of 122.14 g/mol.
Based on its molecular formula C8H7F, Atorvastatin Impurity 61 contains fluorine substitution, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 122.14 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H7F |
| Molecular Weight | 122.14 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
Related Atorvastatin Standards
- Atorvastatin Impurity 112 (CAS 459-57-4)
- Atorvastatin Impurity 52 (CAS 42558-54-3)
- Atorvastatin Impurity 54 (CAS 141942-85-0)
- Atorvastatin Impurity 60 (CAS 124401-38-3)
- Atorvastatin Impurity N6 (CAS 807312-27-2)
- Atorvastatin Impurity N2 (CAS 40281-50-3)
- Atorvastatin Impurity N3 (CAS 77294-82-7)
- Atorvastatin impurity 161 (CAS CATO-C4X-1132161)
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