Furosemide Impurity 47 CAS CATO-C4X-140247
| CAS No. | CATO-C4X-140247 |
| Molecular Formula | C12H10ClNO6S |
| Molecular Weight | 331.73 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 331.73 g/mol gives Furosemide Impurity 47 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Furosemide Impurity 47 (CAS CATO-C4X-140247, C12H10ClNO6S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Furosemide Impurity 47 (C12H10ClNO6S) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 8.0, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 331.73 g/mol, it falls into the moderately-high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H10ClNO6S |
| Molecular Weight | 331.73 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Furosemide Standards
- Furosemide Impurity 25 (CAS 2309462-39-1)
- Furosemide Impurity 9 (CAS CATO-C4X-14029)
- Furosemide (CAS 54-31-9)
- Furosemide EP Impurity A (CAS 4818-59-1)
- Furosemide Impurity 55 (CAS CATO-C4X-140255)
- Furosemide Impurity N3 (CAS 22893-13-6)
- Furosemide Amide Impurity (CAS 4793-47-9)
- Furosemide Impurity 48 Sodium Salt (CAS 133989-65-8（free base）)
Recommended Standards
- N-(3-Chlorophenyl)-2-(5-(3-fluorophenyl)-1,2,4-oxadiazol-3-yl)acetamide (CAS 915925-69-8)
- (2E)-1-(3-Chlorothiophen-2-yl)-3-{[3-(trifluoromethyl)phenyl]amino}prop-2-en-1-one (CAS 339012-79-2)
- N-(3-Chloro-4-fluorophenyl)-8-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxamide (CAS 847411-71-6)
- 1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-3-phenylthiourea (CAS 326814-83-9)
- Atomoxetine EP impurity B (CAS 105314-53-2)
- Sitagliptin Impurity 171 (CAS CATO-C4X-1144171)
- Atorvastatin Impurity 37 (CAS 947586-93-8)
- 2,7,8-Trimethyl-1-phenyl-1H-purin-6(7H)-one (CAS 83325-09-1)
- 4-(4-Chlorobenzoyl)pyridine (CAS 14548-48-2)
- 5-Bromo-1-butyldihydropyrimidine-2,4(1H,3H)-dione (CAS 709-18-2)
- 3-Methyl-1-phenyl-5-thioxo-1H-pyrrol-2(5H)-one (CAS 191084-53-4)
- 2-Phenoxycyclopentan-1-ol (CAS 91969-99-2)
- 2,3-Diphenyl-4H-pyrido[1,2-a]pyrimidin-4-one (CAS 54214-70-9)
- [D-Phe22]Semaglutide (CAS CATO-C4X-2226222)
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