Furosemide EP Impurity A CAS 4818-59-1
| CAS No. | 4818-59-1 |
| Molecular Formula | C12H11ClN2O5S |
| Molecular Weight | 330.74 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Furosemide EP Impurity A (C12H11ClN2O5S) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
CATO supplies Furosemide EP Impurity A (CAS 4818-59-1), a pharmacopoeial impurity reference standard (molecular formula C12H11ClN2O5S, MW 330.74 g/mol) used for the identification and quantification of trace impurities in APIs.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Furosemide EP Impurity A meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H11ClN2O5S |
| Molecular Weight | 330.74 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Furosemide Standards
- Furosemide (CAS 54-31-9)
- Furosemide Impurity 55 (CAS CATO-C4X-140255)
- Furosemide Impurity N3 (CAS 22893-13-6)
- Furosemide Amide Impurity (CAS 4793-47-9)
- Furosemide Impurity 25 (CAS 2309462-39-1)
- Furosemide Impurity 47 (CAS CATO-C4X-140247)
- Furosemide Impurity 9 (CAS CATO-C4X-14029)
- Furosemide Impurity 48 Sodium Salt (CAS 133989-65-8（free base）)
Recommended Standards
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- Simethicone (CAS 8050-81-5)
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Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com