Sorafenib EP Impurity C CAS 320-51-4
| CAS No. | 320-51-4 |
| Molecular Formula | C7H5ClF3N |
| Molecular Weight | 195.57 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Sorafenib EP Impurity C is closely related to a nitrile group, fluorine/chlorine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Sorafenib EP Impurity C (CAS 320-51-4), a pharmacopoeial impurity reference standard (molecular formula C7H5ClF3N, MW 195.57 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Sorafenib EP Impurity C (C7H5ClF3N) is characterized by a nitrile group, fluorine/chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Sorafenib EP Impurity C under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C7H5ClF3N |
| Molecular Weight | 195.57 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Sorafenib Standards
- Sorafenib Impurity 31 (CAS 62476-58-8)
- Sorafenib Impurity 34 (CAS 121-50-6)
- Sorafenib Impurity 49 (CAS 1446410-29-2)
- Sorafenib Impurity 37 (CAS CATO-C4X-112437)
- Sorafenib Impurity 20 (CAS 329-01-1)
- Sorafenib Impurity 54 (CAS 67455-41-8)
- Sorafenib Impurity 46 (CAS 53750-66-6)
- Sorafenib Impurity 57 (CAS 99970-10-2)
Recommended Standards
- 4-Amino-3-chlorobenzotrifluoride (CAS 39885-50-2)
- 2-Chloro-6-fluoroimidazo[1,2-a]pyridine-3-carbonitrile (CAS 1428521-72-5)
- 5-Chloro-2-(trifluoromethyl)aniline (CAS 445-14-7)
- 4-Chloro-3-fluoropyrazolo[1,5-a]pyridine-7-carbonitrile (CAS 2403783-76-4)
- Oxcarbazepine EP Impurity B (CAS 28721-09-7)
- Vericiguat Impurity 23 (CAS CATO-C4X-289623)
- Tedizolid Impurity 40 (CAS 1239662-43-1&1239662-42-0(mixture))
- 5,6-Bis(furan-2-yl)-4-imino-3-phenyl-1H,2H,3H,4H-furo[2,3-d]pyrimidine-2-thione (CAS 685106-49-4)
- 2,4-Dichloro-6-nitrobenzamide (CAS 1803726-83-1)
- 4-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)-2-fluorophenol (CAS 2096994-82-8)
- DMT-2′O-TBDMS-rA (bz) phosphoramidite (CAS 104992-55-4)
- 2-(Ethylamino)propanenitrile (CAS 40651-88-5)
- 4-{[4-(trifluoromethyl)pyrimidin-2-yl]oxy}aniline (CAS 1215670-87-3)
- [Tyr15] Fibrinopeptide B, human (CAS 125455-56-3)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com