Baclofen EP Impurity F CAS 4846-95-1
| CAS No. | 4846-95-1 |
| Molecular Formula | C10H11Cl2NO2 |
| Molecular Weight | 248.11 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Baclofen EP Impurity F (CAS 4846-95-1), a pharmacopoeial impurity reference standard (molecular formula C10H11Cl2NO2, MW 248.11 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Baclofen EP Impurity F (C10H11Cl2NO2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H11Cl2NO2 |
| Molecular Weight | 248.11 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Baclofen Standards
- Baclofen impurity 29 (CAS CATO-C4X-101229)
- Baclofen impurity 4 (CAS 159112-23-9)
- Baclofen impurity 8 (CAS 19411-80-4)
- Baclofen EP Impurity C (CAS 35271-74-0)
- Baclofen impurity 7 (CAS 103857-58-5)
- Baclofen impurity 12 (CAS 232597-00-1)
- Baclofen EP Impurity B (CAS 1141-23-7)
- Baclofen Impurity 37 (CAS CATO-C4X-101237)
Recommended Standards
- 3-Chloro-n-(5-chloro-2-methoxyphenyl)propanamide (CAS 346726-62-3)
- 6,9-Dichloroacridine (CAS 35547-70-7)
- 3-chloro-N-(4-chloro-3-methoxyphenyl)propanamide (CAS 915920-71-7)
- Ethyl 2,4-dichloro-5,6-dimethylnicotinate (CAS 77629-52-8)
- Dalbavancin Impurity 19 (CAS CATO-C4X-160219)
- Trametinib impurity 04 (CAS 871700-25-3)
- Cefadroxil Impurity 28 (CAS CATO-C4X-122428)
- 2-(2-Chloroethyl)-1-methyl-1h-pyrrole (CAS 1314902-61-8)
- 2-Cyclopropyl-6-methylaniline (CAS 2006948-49-6)
- 1-(4-Ethyl-3-methyl-3,4-dihydroisoquinolin-2(1H)-yl)ethanone (CAS 499196-14-4)
- Thiamphenicol Impurity 6 (CAS 21079-44-7)
- 6-Methylhept-6-en-3-one (CAS 89808-51-5)
- Thiobutabarbital (CAS 2095-57-0)
- Pancreatic Polypeptide (rat) (CAS 90419-12-8)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com