Macitentan Impurity 21 CAS CATO-C4X-117521
| CAS No. | CATO-C4X-117521 |
| Molecular Formula | C16H23BrN6O4S2 |
| Molecular Weight | 507.43 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C16H23BrN6O4S2, Macitentan Impurity 21 contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, bromine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 507.43 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a process- or degradation-related impurity, Macitentan Impurity 21 (CAS CATO-C4X-117521, C16H23BrN6O4S2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Macitentan Impurity 21 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C16H23BrN6O4S2 |
| Molecular Weight | 507.43 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 6 |
| Sulfur Atoms | 2 |
Related Macitentan Standards
- Macitentan Impurity 56 (CAS CATO-C4X-117556)
- Macitentan Impurity 16 (CAS 2211059-00-4)
- Macitentan Impurity 57 (CAS CATO-C4X-117557)
- Macitentan Impurity 33 (CAS 1642873-05-9)
- Macitentan Impurity 55 (CAS CATO-C4X-117555)
- Macitentan Impurity N1 (CAS 2443747-63-3)
- Macitentan Impurity 35 (CAS 441798-36-3)
- Macitentan Impurity 32 (CAS 1803092-45-6)
Recommended Standards
- Sitagliptin Impurity 22 (CAS 486460-23-5)
- 5,5'-(Acridine-2,7-diyl)diisophthalic acid (CAS 1527507-79-4)
- 2-((N-(5-(Benzyloxy)-2,4-dichlorophenyl)-4-methylphenyl)sulfonamido)-N,N-dimethylacetamide (CAS 338967-32-1)
- Cyclooctyne-O-amido-PEG2-PFP ester (CAS 2101206-61-3)
- Cyromazine Impurity 2 (CAS 66215-10-9)
- Epalrestat Impurity 54 (CAS 1408072-62-7)
- Ketorolac EP Impurity C (CAS 1026936-07-1)
- 4-Benzylidene-2-methyl-2-oxazolin-5-one (CAS 881-90-3)
- Ethyl 2-(2-((4-methoxybenzyl)sulfonyl)-4,5-diphenyl-1H-imidazol-1-yl)acetate (CAS 339277-84-8)
- Aprepitant impurity 34 (CAS CATO-C4X-237934)
- 3-(5-(Methoxymethyl)-1H-1,2,4-triazol-3-yl)aniline (CAS 1215551-34-0)
- 4-(Hydroxymethyl)picolinaldehyde (CAS 212914-74-4)
- N-ethyl-1-(pyridin-4-yl)ethan-1-amine (CAS 63557-64-2)
- Delta-Sleep Inducing Peptide (CAS 62568-57-4)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com