Citalopram Impurity 15 CAS 488787-59-3
| CAS No. | 488787-59-3 |
| Molecular Formula | C20H23FN2O2 |
| Molecular Weight | 342.41 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Citalopram Impurity 15 is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Citalopram Impurity 15 (CAS 488787-59-3) is a certified pharmaceutical impurity reference standard with the molecular formula C20H23FN2O2 and a molecular weight of 342.41 g/mol.
Structurally, Citalopram Impurity 15 (C20H23FN2O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 10.0, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 342.41 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H23FN2O2 |
| Molecular Weight | 342.41 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Citalopram Standards
- Citalopram EP Impurity A (CAS 64372-56-1)
- Citalopram Impurity 11 (CAS CATO-C4X-110911)
- Citalopram Impurity 14 (CAS CATO-C4X-110914)
- Citalopram Impurity 68 (CAS 481047-48-7)
- Citalopram Impurity 84 (CAS CATO-C4X-110984)
- Citalopram EP Impurity M (CAS 440121-09-5)
- Citalopram Nitrile Oxide (CAS 1346601-93-1)
- Citalopram EP Impurity B (Escitalopram EP Impurity B ) (CAS 411221-53-9)
Recommended Standards
- Escitalopram EP Impurity A(R-Isomer) (CAS CATO-C4X-110920)
- Sildenafil Impurity 296 (CAS CATO-C4X-1128296)
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- Captopril Impurity 30 (CAS CATO-C4X-119030)
- Dexmedetomidine Impurity 92 (CAS CATO-C4X-123092)
- Fosaprepitant impurity 56（S,S,S） (CAS CATO-C4X-116856)
- Terbutaline Impurity 40 (CAS CATO-C4X-118340)
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- N,5,6-Trimethyl-1H-benzo[d]imidazol-2-amine (CAS 107903-00-4)
- Methyl 3-(2-furyl)-1H-pyrazole-5-carboxylate (CAS 34042-72-3)
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- N-(2-Chlorophenyl)-2-(2-mercapto-4-oxo-4,5-dihydro-1,3-thiazol-5-yl)acetamide (CAS 1142200-12-1)
- TAT 14 Peptide (Nrf2 Activator III) (CAS 1362661-34-4)
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