Azathioprine EP Impurity C CAS 4897-25-0
| CAS No. | 4897-25-0 |
| Molecular Formula | C4H4ClN3O2 |
| Molecular Weight | 161.55 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Azathioprine EP Impurity C (CAS 4897-25-0) is a certified pharmaceutical impurity reference standard with the molecular formula C4H4ClN3O2 and a molecular weight of 161.55 g/mol.
Based on its molecular formula C4H4ClN3O2, Azathioprine EP Impurity C contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 161.55 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), Azathioprine EP Impurity C meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C4H4ClN3O2 |
| Molecular Weight | 161.55 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Azathioprine Standards
- Azathioprine EP Impurity D (CAS 6339-54-4)
- Azathioprine Impurity 8 (CAS 50-66-8)
- Azathioprine Impurity 6 (CAS 154-42-7)
- Azathioprine Impurity 9 (CAS 1190008-04-8)
- Azathioprine EP Impurity B (CAS 157930-13-7)
- Azathioprine EP Impurity B (CAS 50-44-2)
- Azathioprine Impurity 21 (CAS 30467-02-8)
- Azathioprine Impurity 12 (CAS 1192-53-6)
Recommended Standards
- Ribavirin Impurity 60 (CAS 21733-05-1)
- Minoxidil Impurity 70 (CAS CATO-C4X-170070)
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- Lercanidipine Impurity 52 (CAS CATO-C4X-136452)
- Piperacillin Impurity 40 (CAS CATO-C4X-173240)
- Arotinolol Impurity 40 (CAS CATO-C4X-185440)
- 2-(4-(1,2,3-Thiadiazol-4-yl)benzyl)isothiazol-3(2H)-one (CAS 918107-72-9)
- 2-[benzyl(methyl)amino]-1-cyclopropylethan-1-ol (CAS 1343058-92-3)
- (2R,3R,4S,5R,6R)-2-(acetoxymethyl)-6-methoxytetrahydro-2H-pyran-3,4,5-triyl triacetate (CAS 4860-85-9)
- [2-(1,3-Benzodioxol-5-yloxy)-5-(trifluoromethyl)-phenyl]amine hydrochloride (CAS 1050509-36-8)
- (1-(2-Chloro-6-fluorobenzyl)-1H-indol-3-yl)methanol (CAS 1427028-63-4)
- Picloram-2-Ethylhexyl Ester (CAS 36374-99-9)
- Tirzepatide Impurity 44 (CAS CATO-C4X-324044)
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