Tiotropium Bromide Impurity 33 CAS 498-45-3
| CAS No. | 498-45-3 |
| Molecular Formula | C8H13NO2 |
| Molecular Weight | 155.19 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Tiotropium Bromide Impurity 33 is closely related to an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Tiotropium Bromide Impurity 33 (CAS 498-45-3, C8H13NO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Tiotropium Bromide Impurity 33 (C8H13NO2) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. The carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H13NO2 |
| Molecular Weight | 155.19 g/mol |
| Appearance | White to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 1 |
Related Tiotropium Standards
- Tiotropium impurity N1 (CAS 487-27-4)
- Tiotropium Bromide Impurity 19 (CAS 498-46-4)
- Tiotropium Impurity 26 (CAS 10299-90-8)
- Tiotropium Bromide Impurity 32 (CAS 1570-95-2)
- Tiotropium Impurity 28 (CAS 59516-66-4)
- Tiotropium Impurity 29 (CAS 213967-57-8)
- Tiotropium Bromide Impurity 17 (CAS CATO-C4X-176417)
- Tiotropium Impurity 34 (CAS 169219-67-4)
Recommended Standards
- Brivaracetam impurity 101 (CAS CATO-C4X-2007101)
- Umeclidinium Impurity 8 (CAS 55022-88-3)
- Brivaracetam Impurity 120 (CAS CATO-C4X-2007120)
- Pregabalin impurity 95 (CAS 164597-78-8)
- Ilaprazole Impurity 40 (CAS 102625-96-7)
- All-Rac-Α-Tocopheryl Acetate EP Impurity D (CAS CATO-C4X-119535)
- Betamethasone Impurity N1 (CAS 910-99-6)
- Atogepant Impurity 58 (CAS CATO-C4X-328558)
- Imastaxime Impurity 2 (CAS CATO-C4X-31352)
- (2-methyl-2H-indazol-7-yl)methanamine hydrochloride (CAS 1400764-43-3)
- 4-(Furan-2-ylmethyl)-1,5-dioxo-2,3,4,5-tetrahydropyrrolo[1,2-a]quinazoline-3a(1H)-carboxylic acid (CAS 847744-17-6)
- Terbutaline impurity 105 (CAS CATO-C4X-1183105)
- 5-Methoxy-1-(p-tolyl)-1H-pyrazole-3-carboxylic acid (CAS 54709-09-0)
- Semaglutide impurity 31 (CAS CATO-C4X-222631)
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