Tiotropium impurity N1 CAS 487-27-4
| CAS No. | 487-27-4 |
| Molecular Formula | C8H13NO2 |
| Molecular Weight | 155.19 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Tiotropium impurity N1 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies Tiotropium impurity N1 (CAS 487-27-4), a pharmacopoeial impurity reference standard (molecular formula C8H13NO2, MW 155.19 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Tiotropium impurity N1 (C8H13NO2) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 3.0, corresponding to approximately 3 ring(s) or double-bond equivalent(s). With a molecular weight of 155.19 g/mol, it falls into the medium-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C8H13NO2 |
| Molecular Weight | 155.19 g/mol |
| Appearance | White to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 1 |
Related Tiotropium Standards
- Tiotropium Bromide Impurity 19 (CAS 498-46-4)
- Tiotropium Bromide Impurity 33 (CAS 498-45-3)
- Tiotropium Impurity 26 (CAS 10299-90-8)
- Tiotropium Bromide Impurity 32 (CAS 1570-95-2)
- Tiotropium Impurity 28 (CAS 59516-66-4)
- Tiotropium Impurity 29 (CAS 213967-57-8)
- Tiotropium Bromide Impurity 17 (CAS CATO-C4X-176417)
- Tiotropium Impurity 34 (CAS 169219-67-4)
Recommended Standards
- Rel-methyl (1R,4S,5R)-2-azabicyclo[2.2.1]heptane-5-carboxylate (CAS 585539-02-2)
- tert-butyl 2-cyano-2-methylacetate (CAS 66476-82-2)
- Rel-ethyl (1S,2R,5R)-3-azabicyclo[3.1.0]hexane-2-carboxylate (CAS 76155-34-5)
- Tranexamic Acid EP Impurity C (CAS 330838-52-3)
- Nalmefene Impurity 19 (CAS CATO-C4X-126819)
- Argatroban Impurity 30 (CAS 153886-69-2)
- Roxithromycin EP Impurity G (CAS 425365-64-6)
- 206996-57-8 L-(+)-Canavanine sulfate salt monohydrate DTXSID30423561 (CAS 206996-57-8)
- tert-Butyl 3-amino-6-bromo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate (CAS 1160247-41-5)
- 3-(2,2,2-Trifluoroethanesulfonyl)benzoic acid (CAS 1094264-43-3)
- 2-(Oxolan-3-yl)-1-phenylethan-1-amine (CAS 1339699-57-8)
- (S)-1-(3,4-dimethylphenyl)but-3-en-1-amine (CAS 1269929-27-2)
- (3β,20S)-20-Formyl-3-hydroxy-5-pregnene (CAS 53906-49-3)
- Tirzepatide Impurity 1 (CAS 2460751-66-8)
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