Tiotropium Impurity 28 CAS 59516-66-4
| CAS No. | 59516-66-4 |
| Molecular Formula | C4H2O7 |
| Molecular Weight | 162.05 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Tiotropium Impurity 28 is closely related to a carbohydrate-derived structure in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Tiotropium Impurity 28 (CAS 59516-66-4, C4H2O7) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a carbohydrate-derived structure, Tiotropium Impurity 28 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 162.05 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C4H2O7 |
| Molecular Weight | 162.05 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >90% |
| Storage | Store at 2-8°C, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1974 |
Related Tiotropium Standards
- Tiotropium impurity N1 (CAS 487-27-4)
- Tiotropium Bromide Impurity 19 (CAS 498-46-4)
- Tiotropium Bromide Impurity 33 (CAS 498-45-3)
- Tiotropium Impurity 26 (CAS 10299-90-8)
- Tiotropium Bromide Impurity 32 (CAS 1570-95-2)
- Tiotropium Impurity 29 (CAS 213967-57-8)
- Tiotropium Bromide Impurity 17 (CAS CATO-C4X-176417)
- Tiotropium Impurity 34 (CAS 169219-67-4)
Recommended Standards
- Propanedioic acid, 2-methyl-, sodium salt (1:2) (CAS 53007-37-7)
- Methyl pentafluoroethyl ketone (CAS 374-41-4)
- Drying pearls Orange (CAS 1327-36-2)
- Pentafluoropropanamidine (CAS 422-62-8)
- Pitavastatin Impurity 13 (CAS 1611499-16-1(free base))
- Vericiguat Impurity 21 (CAS CATO-C4X-289621)
- Oxybutynin EP Impurity C (CAS 1199574-70-3)
- 2-Ethoxy-4-oxo-1,4-dihydroquinoline-3-carbonitrile (CAS 154014-47-8)
- N-[1-(2,5-Dimethoxyphenyl)ethyl]-1-methyl-1H-pyrazol-4-amine (CAS 1153754-43-8)
- 2-(3-Methyl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-4-yl)acetic acid (CAS 1782817-05-3)
- Upadacitinib Impurity 1 (CAS CATO-C4X-24051)
- 2-Amino-2-propylpentanenitrile (CAS 805181-81-1)
- Cytidine 5'-pyrophosphate 2-(Dimethylamino)ethyl Ester Sodium Salt (CAS 119629-11-7)
- Semaglutide Impurity 188 (CAS CATO-C4X-2226188)
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