Tiotropium Bromide Impurity 19 CAS 498-46-4
| CAS No. | 498-46-4 |
| Molecular Formula | C8H13NO2 |
| Molecular Weight | 155.19 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Tiotropium Bromide Impurity 19 (CAS 498-46-4) is a certified pharmaceutical impurity reference standard with the molecular formula C8H13NO2 and a molecular weight of 155.19 g/mol.
Owing to an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage, Tiotropium Bromide Impurity 19 is typically white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 155.19 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), Tiotropium Bromide Impurity 19 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H13NO2 |
| Molecular Weight | 155.19 g/mol |
| Appearance | White to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 1 |
Related Tiotropium Standards
- Tiotropium impurity N1 (CAS 487-27-4)
- Tiotropium Bromide Impurity 33 (CAS 498-45-3)
- Tiotropium Impurity 26 (CAS 10299-90-8)
- Tiotropium Bromide Impurity 32 (CAS 1570-95-2)
- Tiotropium Impurity 28 (CAS 59516-66-4)
- Tiotropium Impurity 29 (CAS 213967-57-8)
- Tiotropium Bromide Impurity 17 (CAS CATO-C4X-176417)
- Tiotropium Impurity 34 (CAS 169219-67-4)
Recommended Standards
- Umeclidinium Impurity 8 (CAS 55022-88-3)
- Pregabalin impurity 95 (CAS 164597-78-8)
- Brivaracetam impurity 101 (CAS CATO-C4X-2007101)
- pregabalin Impurity 36 (CAS 181289-16-7)
- Amiloride Hydrochloride Dihydrate EP Impurity B (CAS 4878-36-8)
- Rizatriptan Impurity 15 (CAS 114094-45-0)
- Iguratimod Impurity 60 (CAS CATO-C4X-182660)
- [1-(3,4-Dichlorophenyl)-1H-1,2,3-triazol-4-yl]methyl N-phenylcarbamate (CAS 338419-30-0)
- Ethyl 2-amino-2-(pyridin-2-yl)acetate hydrochloride (CAS 1910766-97-0)
- 2-Cyano-3-(o-tolyl)propanoic acid (CAS 858215-75-5)
- 1-(2-Phenoxyethyl)-1H-pyrazol-3-amine (CAS 1240570-31-3)
- 2,2'-(Carbonylbis(sulfanediyl))diacetic acid (CAS 65291-49-8)
- 4-Chloro-1,6-dimethyl-1H-pyrrolo[2,3-b]pyridine-5-carbaldehyde (CAS 1638763-59-3)
- Tyr-Proinsulin C-Peptide (55-89) (human) (CAS 139532-11-9)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com