Naproxen EP Impurity A CAS 52079-10-4
| CAS No. | 52079-10-4 |
| Molecular Formula | C13H12O3 |
| Molecular Weight | 216.23 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Naproxen EP Impurity A (CAS 52079-10-4) is a certified pharmaceutical impurity reference standard with the molecular formula C13H12O3 and a molecular weight of 216.23 g/mol.
The molecular framework of Naproxen EP Impurity A (C13H12O3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C13H12O3 |
| Molecular Weight | 216.23 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1971 |
Related Naproxen Standards
- Naproxen Acid (CAS 123050-98-6)
- Naproxen Impurity 2 (CAS 60756-73-2)
- Naproxen EP Impurity I (CAS 23981-47-7)
- Naproxen Impurity N1 (CAS 27602-75-1)
- Naproxen Impurity 6 (CAS 174172-95-3)
- Naproxen Dehydro Impurity (CAS 27602-79-5)
- Naproxen Impurity 41 (CAS CATO-C4X-170841)
- Naproxen Impurity 42 (CAS CATO-C4X-170842)
Recommended Standards
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- Agomelatine Impurity 25 (CAS 6836-22-2)
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- Pitavastatin Impurity 105 (CAS CATO-C4X-1037105)
- Thiocolchicoside EP Impurity H (10-Demethoxy Colchicoside) (CAS CATO-C4X-27704)
- Isosorbide Dinitrate Impurity 9 (CAS 13241-36-6)
- Lercanidipine Impurity 53 (CAS CATO-C4X-136453)
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- Pirbuterol (CAS 38677-81-5)
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- 2-Methylpropyl-d9-amine HCl (CAS 1219799-03-7)
- Peptide YY (3-36) (canine, mouse, porcine, rat) trifluoroacetate salt (CAS 126339-09-1)
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