Avacopan Impurity 8 CAS CATO-C4X-29458
| CAS No. | CATO-C4X-29458 |
| Molecular Formula | C33H34F4N4O3 |
| Molecular Weight | 610.64 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Avacopan Impurity 8 (CAS CATO-C4X-29458, C33H34F4N4O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C33H34F4N4O3, Avacopan Impurity 8 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 610.64 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C33H34F4N4O3 |
| Molecular Weight | 610.64 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 17.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related Avacopan Standards
- Avacopan Impurity 1 (CAS CATO-C4X-29451)
- Avacopan (CAS 1346623-17-3)
- Avacopan Impurity 12 (CAS CATO-C4X-294512)
- Avacopan impurity 7 (CAS 1257868-45-3)
- Avacopan Impurity 9 (CAS CATO-C4X-29459)
- Avacopan Impurity 10 (CAS CATO-C4X-294510)
- Avacopan Impurity 11 (CAS CATO-C4X-294511)
- Avacopan Impurity 4 (CAS 1346623-05-9)
Recommended Standards
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- Candesartan Cilexetil (CAS 145040-37-5)
- Rosuvastatin Impurity 101 (CAS CATO-C4X-1169101)
- Amisulpride EP Impurity F (CAS 71676-01-2)
- Cyanocobalamin EP Impurity E (8-epi-cyanocobalamin) (CAS 41325-63-7)
- H-Gly-Pro-Gly-OH (CAS 2441-63-6)
- 4-Methoxydiphenylmethane (CAS 834-14-0)
- 2-Amino-3-(4-methylphenyl)-4H-chromen-4-one (CAS 883279-39-8)
- 2-Ethoxypyrimidine-5-carboxylic acid (CAS 1242458-51-0)
- 1,4-Dichloro-2-(2-chloroethanesulfonyl)benzene (CAS 790263-68-2)
- 6-Benzooxazol-2-ylbenzothiazol-2-ylamine (CAS 301321-03-9)
- Neuropeptide Y, human (CAS 98264-90-5)
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