Progesterone Impurity N3 CAS 5327-60-6
| CAS No. | 5327-60-6 |
| Molecular Formula | C22H32O3 |
| Molecular Weight | 344.49 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Progesterone Impurity N3 (CAS 5327-60-6), a pharmacopoeial impurity reference standard (molecular formula C22H32O3, MW 344.49 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Progesterone Impurity N3 (C22H32O3) contains a steroid core, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 7.0, corresponding to approximately 7 ring(s) or double-bond equivalent(s). With a molecular weight of 344.49 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H32O3 |
| Molecular Weight | 344.49 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
Related Progesterone Standards
- Progesterone Impurity 46 (CAS CATO-C4X-150246)
- Progesterone Impurity 52 (CAS 14508-05-5)
- Progesterone Impurity 65 (CAS CATO-C4X-150265)
- Progesterone Impurity 69 (CAS CATO-C4X-150269)
- Progesterone Impurity 81 (CAS CATO-C4X-150281)
- Progesterone Impurity 85 (CAS 151122-70-2)
- Progesterone Impurity N38 (CAS 70081-51-5)
- Progesterone Impurity 62 (CAS 87421-42-9)
Recommended Standards
- N-(6-(tert-butyl)-3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)thiophene-2-carboxamide (CAS 303135-81-1)
- Rel-(3aR,4R,7S,7aS)-4-methyl-3a,4,7,7a-tetrahydro-4,7-epoxyisobenzofuran-1,3-dione (CAS 6766-45-6)
- N-((butylamino)thioxomethyl)-2-methyl-4-(1-methylethoxy)benzenesulfonamide (CAS 69210-34-0)
- Retinol Impurity 4 (CAS 801-72-9)
- Levonorgestrel EP Impurity T (CAS 799-43-9)
- Rimegepant Impurity 36 (CAS CATO-C4X-248736)
- Erlotinib Impurity 46 (CAS CATO-C4X-106946)
- 5-(1-Aminobut-3-en-1-yl)-2-methylphenol (CAS 1270541-47-3)
- 3-Hydroxy-1-(o-tolylthio)cyclobutane-1-carboxylic acid (CAS 1480825-48-6)
- 2-(4-Methylphenoxy)-5-[(1H-pyrazol-1-yl)methyl]-1,3-thiazole (CAS 956741-87-0)
- 6-Methyl-2-(methylsulfonyl)pyrimidine-4-carboxylic acid (CAS 1263216-10-9)
- 6-Bromo-N-propylpyridin-2-amine hydrochloride (CAS 1150271-22-9)
- 6-Oxabicyclo[3.1.0]hexane-3-carboxylic acid (CAS 1245806-43-2)
- Semaglutide Impurity 9 (CAS CATO-C4X-22269)
Why CATO?
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- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com