Ibuprofen Impurity 27 CAS 53949-54-5
| CAS No. | 53949-54-5 |
| Molecular Formula | C13H18O3 |
| Molecular Weight | 222.28 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Ibuprofen Impurity 27 (CAS 53949-54-5) is a certified pharmaceutical impurity reference standard with the molecular formula C13H18O3 and a molecular weight of 222.28 g/mol.
Based on its molecular formula C13H18O3, Ibuprofen Impurity 27 contains a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 222.28 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H18O3 |
| Molecular Weight | 222.28 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1972 |
Related Ibuprofen Standards
- Ibuprofen EP Impurity L (CAS 53949-53-4)
- Ibuprofen EP Impurity M (CAS 60057-62-7)
- Ibuprofen Impurity 53 (CAS CATO-C4X-108253)
- Ibuprofen Methyl Ester (CAS 61566-34-5)
- Ibuprofen EP Impurity J (CAS 65813-55-0)
- Ibuprofen EP Impurity J (CAS CATO-C4X-1082148)
- (S)-(+)-Ibuprofen Acid Chloride (CAS 115588-20-0)
- Ibuprofen Impurity 58 (CAS 80336-66-9)
Recommended Standards
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- Olaparib Impurity 39 (CAS 458535-34-7)
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