Ibuprofen EP Impurity L CAS 53949-53-4
| CAS No. | 53949-53-4 |
| Molecular Formula | C13H18O3 |
| Molecular Weight | 222.28 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 222.28 g/mol gives Ibuprofen EP Impurity L distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Ibuprofen EP Impurity L (CAS 53949-53-4, C13H18O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Ibuprofen EP Impurity L (C13H18O3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. It is notably hygroscopic, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Ibuprofen EP Impurity L meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H18O3 |
| Molecular Weight | 222.28 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1972 |
Related Ibuprofen Standards
- Ibuprofen EP Impurity M (CAS 60057-62-7)
- Ibuprofen Impurity 27 (CAS 53949-54-5)
- Ibuprofen Impurity 53 (CAS CATO-C4X-108253)
- Ibuprofen Methyl Ester (CAS 61566-34-5)
- Ibuprofen EP Impurity J (CAS 65813-55-0)
- Ibuprofen EP Impurity J (CAS CATO-C4X-1082148)
- (S)-(+)-Ibuprofen Acid Chloride (CAS 115588-20-0)
- Ibuprofen Impurity 58 (CAS 80336-66-9)
Recommended Standards
- 1H-Pyrazole-4-carboxaldehyde,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl- 4-Antipyrinecarboxaldehyde 4-Formylantipyrine 950-81-2 Antipyraldehyde Antipyrinaldehyd Antipyrine, 4-formyl- Febranine NSC-60408 NSC60408 (CAS 950-81-2)
- 4-(Acetylmethylamino)-1-(3-pyridyl)-1-butanol 4-(Acetylmethylamino)-1-(3-pyridyl)-1-butanol-d6 887352-16-1 N-(4-Hydroxy-4-pyridin-3-yl-butyl)-N-methyl-acetamide N-(4-Hydroxy-4-pyridin-3-yl-butyl)-N-methyl-acetamide-d6 (CAS 887352-16-1)
- 1412AF 4-(4-Ethoxy-3-methyl-phenyl)-butyric acid 878431-90-4 C13H18O3 (CAS 878431-90-4)
- Olmesartan Impurity 30 (CAS 157356-73-5)
- Norfloxacin Impurity 52 (CAS 7251-32-3)
- Ponatinib Impurity 45 (CAS CATO-C4X-226945)
- Levofloxacin Impurity 37 (CAS 2130840-90-1)
- 2-Nitro-N'-(pyridin-3-ylmethylene)benzohydrazide (CAS 19209-73-5)
- 1-(2-(1,1,2,2-Tetrafluoroethoxy)phenyl)ethan-1-one (CAS 1417499-00-3)
- 4-Chloro-N-(4-oxo-3,4,5,6,7,8-hexahydroquinazolin-2-yl)benzamide (CAS 338401-48-2)
- 4-(2-aminophenoxy)azetidin-2-one (CAS 1909318-85-9)
- 3,4-Bis(trifluoromethyl)-1H-pyrazole (CAS 19968-19-5)
- 3-(1,1-Dioxidothiomorpholino)propanoic acid (CAS 849928-19-4)
- Fragment-[3-31]-Semaglutide (CAS CATO-C4X-2226113)
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