Ivacaftor Impurity 14 CAS 54535-22-7
| CAS No. | 54535-22-7 |
| Molecular Formula | C14H17NO4 |
| Molecular Weight | 263.29 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Ivacaftor Impurity 14 (CAS 54535-22-7), a pharmacopoeial impurity reference standard (molecular formula C14H17NO4, MW 263.29 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Ivacaftor Impurity 14 (C14H17NO4) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 7.0, corresponding to approximately 7 ring(s) or double-bond equivalent(s). With a molecular weight of 263.29 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Ivacaftor Impurity 14 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H17NO4 |
| Molecular Weight | 263.29 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1972 |
| Nitrogen Atoms | 1 |
Related Ivacaftor Standards
- Ivacaftor Impurity 3 (CAS 873055-57-3)
- Ivacaftor Impurity 10 (CAS 873055-58-4)
- Ivacaftor impurity 17 (CAS CATO-C4X-296417)
- Ivacaftor Impurity 4 (CAS 873055-55-1)
- Ivacaftor Impurity 7 (CAS 52980-28-6)
- Ivacaftor Impurity 9 (CAS 26892-90-0)
- Ivacaftor Impurity 12 (CAS CATO-C4X-296412)
- Ivacaftor Impurity 6 (CAS 873054-39-8)
Recommended Standards
- Mirogabalin Impurity 207 (CAS CATO-C4X-2924207)
- 3-Hydroxy-2-naphthanilide (CAS 92-77-3)
- Amikacin Impurity 21 (CAS 40371-54-8)
- Ethyl 2-(benzamidomethyl)-3-oxobutanoate (CAS 69396-18-5)
- Valsartan Impurity 144 (CAS 149690-12-0)
- Fexofenadine Impurity 35 (CAS CATO-C4X-179435)
- Pyridoxine Impurity 24 (CAS 76963-36-5)
- 1-((M-tolyloxy)methyl)cyclopentan-1-ol (CAS 1482642-00-1)
- AZD-9291 Impurity 6 (CAS CATO-C4X-11276)
- 3-Benzothiazol-2-yl-4-[3-(4-chloro-phenoxy)-phenyl]-but-3-enoic acid (CAS 749214-71-9)
- 2-Ethoxy-5-methoxy-benzaldehyde (CAS 39206-04-7)
- Pyridine-3,5-dicarbohydrazide (CAS 15420-53-8)
- Testosterone Impurity 32 (CAS CATO-C4X-132632)
- Semaglutide impurity 62 (CAS CATO-C4X-222662)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com