Cloperastine Impurity 1 CAS 5630-78-4
| CAS No. | 5630-78-4 |
| Molecular Formula | C20H24ClNO |
| Molecular Weight | 329.86 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Cloperastine Impurity 1 is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Cloperastine Impurity 1 (CAS 5630-78-4, C20H24ClNO) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Cloperastine Impurity 1 (C20H24ClNO) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Cloperastine Impurity 1 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C20H24ClNO |
| Molecular Weight | 329.86 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Cloperastine Standards
- (R)-Cloperastine (CAS 132301-91-8)
- Cloperastine (CAS 3703-76-2)
- Cloperastine impurity 8 (CAS 132301-89-4)
- Cloperastine Impurity 2 (CAS 4960-10-5)
- Cloperastine Impurity 5 (CAS 75842-85-2)
- Cloperastine Impurity 3 (CAS 6954-45-6)
- Cloperastine Hydrochloride (CAS 14984-68-0)
- (S)-Cloperastine Fendizoate (Levocloperastine Fendizoate) (CAS 220329-19-1)
Recommended Standards
- Clemastine Impurity 23 (CAS CATO-C4X-183723)
- 5-(4-Chlorophenyl)-4-(2-isopropylphenyl)-4h-1,2,4-triazole-3-thiol (CAS 380346-21-4)
- 2,3,5,6-Tetrachloro-4-(trifluoromethyl)benzoyl fluoride (CAS 117338-22-4)
- 3-{[(4-chlorophenyl)methyl]sulfanyl}-1-[(3-methylphenyl)methyl]-1H-1,2,4-triazole (CAS 866131-04-6)
- Piperazine Impurity 10 (CAS CATO-C4X-242710)
- Vardenafil Impurity 36 (CAS 224788-36-7)
- Topiroxostat Impurity 49 (CAS 14906-59-3)
- 1-(2-(1,1-Dioxidothietan-3-yl)ethyl)guanidine (CAS 1871797-33-9)
- N-Methyl-1-(2-(thiophen-2-yl)thiazol-4-yl)methanamine (CAS 933701-68-9)
- 8-Chloro-6-methyl-2-phenylquinoline (CAS 22960-24-3)
- tert-Butyl 4-(6-(methoxycarbonyl)pyridin-3-yl)piperazine-1-carboxylate (CAS 1354355-85-3)
- 1-(6-Amino-1,3-benzodioxol-5-yl)piperidin-2-one (CAS 1366386-67-5)
- 3-(Aminomethyl)cyclohexanol (CAS 116650-26-1)
- Neuropeptide S (rat) (CAS 412938-75-1)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com