Diclofenac EP Impurity E CAS 59-48-3
| CAS No. | 59-48-3 |
| Molecular Formula | C8H7NO |
| Molecular Weight | 133.15 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Diclofenac EP Impurity E (CAS 59-48-3), a pharmacopoeial impurity reference standard (molecular formula C8H7NO, MW 133.15 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Diclofenac EP Impurity E (C8H7NO) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 6.0, corresponding to approximately 6 ring(s) or double-bond equivalent(s). With a molecular weight of 133.15 g/mol, it falls into the low-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Diclofenac EP Impurity E meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H7NO |
| Molecular Weight | 133.15 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 1 |
Related Diclofenac Standards
- Diclofenac Sodium Impurity 32 (CAS 4746-61-6)
- Diclofenac Impurity 19 (CAS 1205-40-9)
- Diclofenac impurity 7 (CAS 2563-99-7)
- Diclofenac Impurity N1 (CAS 131023-43-3)
- Diclofenac Impurity 40 (CAS CATO-C4X-105140)
- Diclofenac sodium Impurity 6 (CAS 70172-33-7)
- Diclofenac impurity 4 (CAS 1928-49-0)
- Diclofenac Impurity 21 (CAS 105836-68-8)
Recommended Standards
- 6-methyl-5H-Pyrrolo[3,2-d]pyrimidine 91724-58-2 ZLE0023 zlchem 1248 (CAS 91724-58-2)
- Axitinib Impurity 86 (CAS 1824099-80-0)
- 4-Cyanobenzyl alcohol (CAS 874-89-5)
- Axitinib Impurity 87 (CAS 1824338-82-0)
- Tibolone EP Impurity A (CAS CATO-C4X-240312)
- Bosutinib Impurity 15 (CAS 380843-81-2)
- Tadalafil Impurity 153 (CAS CATO-C4X-1087153)
- n-(2-Aminoethyl)-3-phenyl-1,2,4-oxadiazole-5-carboxamide (CAS 924871-64-7)
- (trans-4-phenylpiperidin-3-yl)methanol (CAS 105812-73-5)
- 5-Fluoro-4-hydroxy-2H-chromen-2-one (CAS 799262-09-2)
- 3,4-Dibromo-N,N-dimethylaniline (CAS 60469-89-8)
- 2-(4-Boc-Aminopiperidino)pyridine (CAS 252578-12-4)
- 3-Bromo-5-(3,6-dihydro-2H-pyran-4-yl)-1-methyl-1H-pyrazole (CAS 1629892-51-8)
- Tau Peptide (301-315) trifluoroacetate salt (CAS 330456-48-9)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com