Nicotine Impurity 6 CAS 591-22-0
| CAS No. | 591-22-0 |
| Molecular Formula | C7H9N |
| Molecular Weight | 107.15 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Nicotine Impurity 6 is closely related to a nitrile group, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Nicotine Impurity 6 (CAS 591-22-0, C7H9N) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Nicotine Impurity 6 (C7H9N) is characterized by a nitrile group, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Nicotine Impurity 6 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H9N |
| Molecular Weight | 107.15 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 1 |
Related Nicotine Standards
- Nicotine Related Compound 6 (CAS 1657-32-5)
- Nicotine Related Compound 7 (CAS 15268-31-2)
- Nicotine Impurity 7 (CAS 3222-49-9)
- Nicotine Impurity 8 (CAS 29681-45-6)
- Nicotine Impurity 21 (CAS 769-49-3)
- Nicotine Impurity C34 (CAS 525-74-6)
- Nicotine EP Impurity G (R-Isomer) (CAS 34366-21-7)
- Nicotine EP Impurity G (CAS 494-52-0)
Recommended Standards
- Lacosamide EP Impurity J (CAS 100-46-9)
- Dimetindene EP Impurity A (CAS 100-71-0)
- 2,3-dimethylpyridine (CAS 583-61-9)
- o-Toluidine (CAS 95-53-4)
- Chlorphenamine Impurity 67 (CAS CATO-C4X-118867)
- Hydrochlorothiazide Impurity 20 (CAS 82205-98-9)
- Clopidogrel Impurity 45 (Mixture of Diastereomers) (CAS CATO-C4X-102945)
- 5-Nitro-2-pyridinecarboxylic Acid Ethyl Ester (CAS 30563-98-5)
- N-Cyclopentyl-5-(4-ethylphenyl)-2-(trifluoromethyl)pyrimidin-4-amine (CAS 917895-60-4)
- 1-((1H-pyrazol-1-yl)methyl)cyclopropane-1-carboxylic acid hydrochloride (CAS 1255717-43-1)
- 4-Chloro-2-fluoro-5-methylacetophenone (>90%) (CAS 177211-26-6)
- 1,1,1-Trifluoro-4-(5-fluoro-2,3-dihydrobenzofuran-7-yl)-4-methyl-2-(((2-methylquinolin-5-yl)amino)methyl)pentan-2-ol (CAS 1609049-24-2)
- 4-Butyl-N-(4-(tert-butyl)phenyl)aniline (CAS 398483-80-2)
- Compstatin control peptide (CAS 301544-78-5)
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