Midazolam EP Impurity E DiMaleate Salt CAS 59469-29-3
| CAS No. | 59469-29-3 |
| Molecular Formula | C16H15ClFN3 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Midazolam EP Impurity E DiMaleate Salt meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Midazolam EP Impurity E DiMaleate Salt (CAS 59469-29-3) is a certified pharmaceutical impurity reference standard with the molecular formula C16H15ClFN3C4H4O4 and a molecular weight of 419.84 g/mol.
The molecular framework of Midazolam EP Impurity E DiMaleate Salt (C16H15ClFN3C4H4O4) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C16H15ClFN3 2*C4H4O4 |
| Molecular Weight | 419.84 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1973 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related Midazolam Standards
- Midazolam N-β-D-Glucuronide (~90%, contains ~10% inorganic salts) (CAS 1033824-50-8)
- Midazolam EP Impurity I (CAS 112811-67-3)
- Midazolam EP Impurity H (CAS 119401-13-7)
- Midazolam 2,5-Dioxide-d6 (CAS 1215321-98-4)
- MidazolaM-d6 (CAS 1246819-79-3)
- Midazolam Impurity 20 (CAS 151921-06-1)
- Midazolam Impurity 14 (CAS 2531288-23-8)
- Midazolam EP Impurity F (CAS 2886-65-9)
Recommended Standards
- Upadacitinib Impurity 54 (CAS 406-11-1)
- Trelagliptin Impurity 54 (CAS 1261686-95-6)
- Linagliptin Impurity 30 (CAS CATO-C4X-110130)
- Ethyl 3-Bromopropionate-2,2,3,3-d4 (CAS 14341-55-0)
- 2-Amino-N-propylacetamide hydrochloride (CAS 67863-04-1)
- MES half sodium salt (CAS 117961-21-4)
- Methyl 3-oxo-5-phenylpentanoate (CAS 30414-58-5)
- Tert-butyl (4-bromo-1-methyl-1H-pyrazol-3-yl)(methyl)carbamate (CAS 1619991-12-6)
- 5-Chloro-5H-dibenzo[a,d][7]annulene (CAS 18506-04-2)
- (Des-Thr7)-Glucagon trifluoroacetate salt (CAS 1802078-28-9)
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