Midazolam EP Impurity J CAS 59469-08-8
| CAS No. | 59469-08-8 |
| Molecular Formula | C18H17ClFN3 |
| Molecular Weight | 329.80 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO manufactures Midazolam EP Impurity J under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
CATO supplies Midazolam EP Impurity J (CAS 59469-08-8), a pharmacopoeial impurity reference standard (molecular formula C18H17ClFN3, MW 329.80 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution, Midazolam EP Impurity J is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 329.80 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C18H17ClFN3 |
| Molecular Weight | 329.80 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1973 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related Midazolam Standards
- Midazolam Impurity 40 (CAS CATO-C4X-150940)
- Midazolam-d5 (Major) Discontinued See M343003 (CAS 395067-42-2)
- Midazolam EP Impurity A (CAS 59468-07-4)
- Midazolam Impurity 28 (CAS CATO-C4X-150928)
- 【禁售不询】Midazolam (CAS 59467-70-8)
- Midazolam EP Impurity B (CAS 59469-74-8)
- Midazolam Impurity 25 (CAS CATO-C4X-150925)
- Midazolam Impurity 1 (CAS 59468-90-5)
Recommended Standards
- Tert-butyl (R)-(8-chloro-4-oxo-2,3,4,5-tetrahydropyrido[4,3-b][1,4]thiazepin-3-yl)carbamate (CAS CATO-CIM-100317)
- 2-[2-(4-chlorophenyl)-4-phenyl-1,3-thiazol-5-yl]ethanoate 2-[2-(4-chlorophenyl)-4-phenyl-5-thiazolyl]acetate 23821-72-9 A816923 (CAS 23821-72-9)
- 2,3-Dibromo-5-(bromomethyl)pyridine (CAS 1003859-12-8)
- N'-[(1Z)-(4-Chlorophenyl)methylidene]-3-(1H-pyrrol-1-yl)thiophene-2-carbohydrazide (CAS 478062-83-8)
- Levofloxacin Impurity 62 (CAS CATO-C4X-137162)
- Edoxaban Impurity 10 (CAS CATO-C4X-106310)
- Lacosamide Impurity 46 (CAS 1253790-25-8)
- 4-(Difluoromethyl)-2-iodo-1-methylbenzene (CAS 1261862-43-4)
- Calcium 2-oxopentanedioate xhydrate (CAS 402726-78-7)
- (S,E)-tert-Butyl 3-(oxiran-2-yl)acrylate (CAS 1679347-22-8)
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- 1-Ethyl-4-((4-(piperazin-1-yl)pyridin-3-yl)sulfonyl)piperazine (CAS 1352506-35-4)
- Thiol-PEG8-alcohol (CAS 791620-96-7)
- Semaglutide impurity 107 (CAS CATO-C4X-2226107)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com