Doxorubicin EP Impurity C HBr CAS 60873-68-9
| CAS No. | 60873-68-9 |
| Molecular Formula | C27H28BrNO10 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Doxorubicin EP Impurity C HBr (CAS 60873-68-9, C27H28BrNO10HBr) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Doxorubicin EP Impurity C HBr (C27H28BrNO10HBr) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution. The molecule exhibits a degree of unsaturation (DBE) of 13.0, corresponding to approximately 13 ring(s) or double-bond equivalent(s). With a molecular weight of 687.33 g/mol, it falls into the high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C27H28BrNO10 HBr |
| Molecular Weight | 687.33 g/mol |
| Purity | >75% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1974 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Doxorubicin Standards
- Doxorubicin Impurity 7 (CAS 105612-58-6)
- Doxorubicin Impurity N19 (CAS 106401-68-7)
- Doxorubicin Impurity 5 (CAS 1159977-23-7)
- Doxorubicin EP Impurity B (CAS 148218-14-8)
- Doxorubicin-hydrazone-caproyl-maleimide (CAS 151038-96-9)
- Doxorubicin Impurity N2 HCl (CAS 18977-93-0)
- Doxorubicin Dimer Impurity 23 (CAS 201278-93-5)
- Doxorubicin Impurity 8 (CAS 20982-41-6)
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