Triamcinolone Acetonide EP Impurity A CAS 124-94-7
| CAS No. | 124-94-7 |
| Molecular Formula | C21H27FO6 |
| Molecular Weight | 394.43 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Triamcinolone Acetonide EP Impurity A is closely related to a flavonoid core, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Triamcinolone Acetonide EP Impurity A (CAS 124-94-7) is a certified pharmaceutical impurity reference standard with the molecular formula C21H27FO6 and a molecular weight of 394.43 g/mol.
Owing to a flavonoid core, a hydroxyl group, an ether linkage, fluorine substitution, Triamcinolone Acetonide EP Impurity A is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 394.43 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Triamcinolone Acetonide EP Impurity A meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H27FO6 |
| Molecular Weight | 394.43 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
Related Triamcinolone Standards
- Triamcinolone Acetonide Impurity 43 (CAS CATO-C4X-132643)
- Triamcinolone EP Impurity C (CAS 337-02-0)
- Triamcinolone Acetonide Impurity 8 (Pretriamcinolone) (CAS CATO-C4X-13268)
- Triamcinolone Acetonide Impurity 36 (CAS 159210-07-8)
- Triamcinolone Impurity 10 (CAS 3800-28-0)
- Triamcinolone Acetonide Impurity 53 (CAS 61618-63-1)
- Triamcinolone Acetonide Impurity N2 (CAS 1893-84-1)
- Triamcinolone Acetonide EP Impurity B (CAS 1260149-96-9)
Recommended Standards
- N-Nitroso N-Devaleryl Valsartan Methyl Ester Impurity 89 (mixture of isomers) (CAS CATO-C4X-105789)
- Fluvoxamine EP Impurity F-D4 N-nitroso (CAS CATO-C4X-195151)
- Valsartan Impurity 138 (CAS CATO-C4X-1057138)
- ZHC-116 Impurity 6 (CAS CATO-C4X-23886)
- Siponimod Impurity 36 (CAS CATO-C4X-247236)
- Vardenafil Impurity 35 (CAS CATO-C4X-101735)
- Rosuvastatin Impurity 260 (CAS CATO-C4X-1169260)
- 4-Butoxy-1,2-dichlorobenzene (CAS 16505-70-7)
- 2-(2-Bromo-5-(difluoromethyl)-3-methylpyridin-4-yl)acetonitrile (CAS 1805935-12-9)
- 2-(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl) 1-(1,1-dimethylethyl) 1,2-piperidinedicarboxylate (CAS 2055988-81-1)
- 6-(2,6-Dichloro-3,5-dimethoxyphenyl)-N-(2-methyl-6-nitrophenyl)quinazolin-2-amine (CAS 1538605-09-2)
- 7-Hydroxy-3-(2-(trifluoromethoxy)phenyl)-2h-chromen-2-one (CAS 951996-47-7)
- 2-(5-Bromo-2-methoxyphenyl)acetonitrile (CAS 7062-40-0)
- Semaglutide impurity 51 (CAS CATO-C4X-222651)
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