Amitriptyline Hydrochloride EP Impurity B CAS 6202-23-9
| CAS No. | 6202-23-9 |
| Molecular Formula | C20H21N |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO manufactures Amitriptyline Hydrochloride EP Impurity B under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
As a process- or degradation-related impurity, Amitriptyline Hydrochloride EP Impurity B (CAS 6202-23-9, C20H21NHCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution, Amitriptyline Hydrochloride EP Impurity B is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 311.85 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C20H21N HCl |
| Molecular Weight | 311.85 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Amitriptyline Standards
- Amitriptyline EP Impurity D (CAS 1159-03-1)
- Amitriptyline EP Impurity F (CAS 1159-82-6)
- Amitriptyline EP Impurity A (CAS 1210-35-1)
- Amitriptyline Hydrochloride - Impurity F (Oxalate Salt) (CAS 1246833-15-7)
- Amitriptyline-13C3 Hydrochloride (CAS 1329837-86-6)
- Amitriptyline-d6 Hydrochloride (CAS 203645-63-0)
- Amitriptyline EP Impurity C-d3 HCl (CAS 203784-52-5)
- Amitriptyline EP Impurity E HCl (Mixture of Diastereomers) (CAS 26360-49-6(free base))
Recommended Standards
- Vonoprazan Impurity 200 (CAS CATO-C4X-1020200)
- Celecoxib Impurity 40 (CAS 4392-54-5)
- Valsartan Impurity 37 (CAS CATO-C4X-105737)
- 2-((2-Iodophenyl)amino)-2-oxoacetic acid (CAS 1156070-80-2)
- N-((1-Benzylpyrrolidin-3-yl)methyl)propan-2-amine (CAS 91189-15-0)
- 2-Amino-4-hydroxymethylthiazole (CAS 51307-43-8)
- 4-Chloro-6-methoxy-N,N-dimethylpyrimidin-2-amine (CAS 13012-26-5)
- 2-(Pyrimidin-4-yl)acetonitrile (CAS 794522-90-0)
- .alpha.-Pyracin 4543-56-0 7-Hydroxy-6-methylfuro[3,4-c]pyridin-3(1H)-one 7-hydroxy-6-methyl-1H-furo[3,4-c]pyridin-3-one NSC15983 Pyracin-5 Pyridoxic acid .gamma.-lactone Pyridoxic acid, .gamma.-lactone {Furo[3,4-c]pyridin-3(1H)-one,} 7-hydroxy-6-methyl- (CAS 4543-56-0)
- (Des-Thr7)-Glucagon trifluoroacetate salt (CAS 1802078-28-9)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com