Metoprolol USP Related Compound B CAS 56718-76-4
| CAS No. | 56718-76-4 |
| Molecular Formula | C12H17ClO3 |
| Molecular Weight | 244.71 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Metoprolol USP Related Compound B.
As a process- or degradation-related impurity, Metoprolol USP Related Compound B (CAS 56718-76-4, C12H17ClO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Metoprolol USP Related Compound B (C12H17ClO3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 4.0, corresponding to approximately 4 ring(s) or double-bond equivalent(s). With a molecular weight of 244.71 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Metoprolol USP Related Compound B under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C12H17ClO3 |
| Molecular Weight | 244.71 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1973 |
| Halogen Content | Cl-containing |
Related Metoprolol Standards
- Metoprolol Impurity 51 (CAS 2517349-25-4)
- Metoprolol Impurity 47 (CAS CATO-C4X-136747)
- Metoprolol EP Impurity A (CAS 109632-08-8)
- Metoprolol EP Impurity H (CAS 62572-94-5)
- Metoprolol Impurity 10 (CAS 131564-70-0)
- Metoprolol Impurity 27 (CAS 40167-10-0)
- Metoprolol EP Impurity D (CAS 62572-90-1)
- Metoprolol impurity 1 (CAS 150332-88-0)
Recommended Standards
- 1-Chloro-4-(2,2-diethoxyethoxy)benzene (CAS 41964-04-9)
- 1-chloro-3-(2,2-diethoxyethoxy)benzene (CAS 86912-81-4)
- Ethyl 2-(4-chloro-3,5-dimethyl-1h-pyrazol-1-yl)butanoate (CAS 1005592-59-5)
- 1-(Chloromethyl)-4-[2-(2-methoxyethoxy)ethoxy]benzene (CAS 314286-40-3)
- Vortioxetine Impurity 137 (CAS CATO-C4X-1056137)
- Dasatinib Impurity 24 (CAS CATO-C4X-160724)
- Pemafibrate Impurity 43 (CAS CATO-C4X-290343)
- 2-Amino-N-(2,6-dichlorobenzyl)acetamide (CAS 1353978-06-9)
- 2-(Azidomethyl)-3,5-dimethylpyridin-4-ol (CAS 1211462-01-9)
- 4-(Trimethylsilyl)benzoic Acid (CAS 15290-29-6)
- 2-Carbamoylpyridine-3-boronic acid (CAS 1412415-69-0)
- Norcocaethylene hydrochloride (CAS 362044-01-7)
- 4-Hydroxy-1-[(5-methylfuran-2-yl)methyl]-3-[(2E)-3-phenylprop-2-en-1-yl]-1,2-dihydropyridin-2-one (CAS 478033-65-7)
- Heme iron polypeptide(Hematin) (CAS 14875-96-8)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com