Metoprolol EP Impurity N CAS 6452-57-9
| CAS No. | 6452-57-9 |
| Molecular Formula | C6H15NO2 |
| Molecular Weight | 133.19 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Metoprolol EP Impurity N is closely related to an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Metoprolol EP Impurity N (CAS 6452-57-9) is a certified pharmaceutical impurity reference standard with the molecular formula C6H15NO2 and a molecular weight of 133.19 g/mol.
Owing to an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage, Metoprolol EP Impurity N is typically white to off-white liquid. Its solid-state physicochemical attributes — including a molecular weight of 133.19 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Metoprolol EP Impurity N meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H15NO2 |
| Molecular Weight | 133.19 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 0.0 |
| CAS Registry Year (est.) | 1958 |
| Nitrogen Atoms | 1 |
Related Metoprolol Standards
- Metoprolol EP Impurity G (CAS 501-94-0)
- Metoprolol Impurity 31 (CAS 942499-01-6)
- Metoprolol Impurity 37 (CAS 488-17-5)
- Metoprolol Process Impurity 4 (CAS 84803-56-5)
- Metoprolol Impurity 12 (CAS 32846-01-8)
- Metoprolol EP Impurity B (CAS 56718-71-9)
- Metoprolol Impurity 23 (CAS 330976-39-1)
- Metoprolol Impurity 26 (CAS 69628-98-4)
Recommended Standards
- Levocetirizine Impurity 50 (CAS 1074-42-6)
- Pioglitazone impurity 28 (CAS 5408-74-2)
- Linezolid Impurity 81 (CAS 38711-20-5)
- Indapamide Impurity 22 (CAS 6872-06-6)
- Paliperidone Impurity 51 (CAS CATO-C4X-172451)
- Bumetanide Impurity 135 (CAS 30170-22-0)
- Adrenaline Impurity 17 HCl (CAS 29705-82-6)
- 5-Fluoro-1-(piperazin-1-yl)isoquinoline (CAS 1207448-34-7)
- DL-alpha-Amino-2-thiopheneacetic Acid (CAS 21124-40-3)
- 3-(2-furyl)-1-(4-methylphenyl)-1H-pyrazole-5-carboxylic acid (CAS 882238-45-1)
- 2-Amino-3-(2,4-dichloro-5-fluorophenyl)propanoic acid (CAS 1259982-14-3)
- 5-Aminobicyclo[2.2.1]heptan-2-ol (CAS 223595-57-1)
- (4-(4-Benzylpiperazin-1-yl)phenyl)methanol (CAS 325796-34-7)
- Semaglutide impurity 64 (CAS CATO-C4X-222664)
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