5-Fluorouracil N-β-D-Glucuronide CAS 66048-45-1
| CAS No. | 66048-45-1 |
| Molecular Formula | C10H11FN2O8 |
| Molecular Weight | 306.20 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
5-Fluorouracil N-β-D-Glucuronide (C10H11FN2O8) contains a carbohydrate-derived structure, an amide group, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
5-Fluorouracil N-β-D-Glucuronide (CAS 66048-45-1), molecular formula C10H11FN2O8 and molecular weight 306.20 g/mol, is a CATO reference standard with documented purity and traceability.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H11FN2O8 |
| Molecular Weight | 306.20 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1975 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Fluorouracil Standards
- Fluorouracil Impurity 20 (CAS CATO-C4X-164920)
- Fluorouracil Impurity 29 (CAS 61251-77-2)
- Fluorouracil Impurity N2 (CAS 55996-26-4)
- Fluorouracil Impurity 17 (CAS 5440-00-6)
- Fluorouracil Impurity 27 (CAS 2566704-13-8)
- Fluorouracil Impurity 18 (CAS CATO-C4X-164918)
- 5-Fluorouracil N-β-D-Glucuronide Methyl Ester, 2,3,4-Triacetate (CAS 77476-81-4)
- Fluorouracil Impurity 23 (CAS CATO-C4X-164923)
Recommended Standards
- 5-fluoro-2-nitrophenyl 4-nitrobenzoate (CAS 219689-76-6)
- methyl 7-amino-6-bromo-5-methyl-1,8-naphthyridine-3-carboxylate (CAS 2691878-80-3)
- 5-Bromo-N,N-diethyl-2-phenylpyrimidin-4-amine (CAS 823796-33-4)
- N-(5-bromo-2-ethoxybenzyl)aniline (CAS 664318-85-8)
- L-Malic Acid Disodium Salt Monohydrate (CAS 207511-06-6)
- 4-Hydroxy Thalidomide (CAS 64567-60-8)
- N1,N3-diphenylisophthalamide (CAS 13111-32-5)
- N-(benzo[d]thiazol-6-yl)-2-bromoacetamide (CAS 916791-25-8)
- 3-methylpyridazine (CAS 1632-76-4)
- Theophylline Impurity 10 (CAS CATO-C4X-182310)
- 2-(2-((3aS,6aS)-5-(2-Methoxyphenyl)-4,6-dioxo-1,3a,4,5,6,6a-hexahydropyrrolo[3,4-c]pyrazol-3-yl)-2-oxoethyl)isoindoline-1,3-dione (CAS 956934-85-3)
- 4-Fluoro-N-(4-((3-(trifluoromethyl)phenyl)sulfonyl)phenyl)benzamide (CAS 339104-92-6)
- 1-(9-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-yl)-3-phenylurea (CAS 33467-20-8)
- D-γ-Glu20-Side-Tirzepatide (CAS CATO-CPTD788929)
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