5-Fluorouracil N-β-D-Glucuronide Methyl Ester, 2,3,4-Triacetate CAS 77476-81-4
| CAS No. | 77476-81-4 |
| Molecular Formula | C17H19FN2O11 |
| Molecular Weight | 446.34 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
5-Fluorouracil N-β-D-Glucuronide Methyl Ester, 2,3,4-Triacetate (CAS 77476-81-4) is a high-purity analytical reference standard with the molecular formula C17H19FN2O11 and a molecular weight of 446.34 g/mol.
The molecular framework of 5-Fluorouracil N-β-D-Glucuronide Methyl Ester, 2,3,4-Triacetate (C17H19FN2O11) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C17H19FN2O11 |
| Molecular Weight | 446.34 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1979 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Fluorouracil Standards
- 5-Fluorouracil N-β-D-Glucuronide (CAS 66048-45-1)
- Fluorouracil Impurity 20 (CAS CATO-C4X-164920)
- Fluorouracil Impurity 29 (CAS 61251-77-2)
- Fluorouracil Impurity N2 (CAS 55996-26-4)
- Fluorouracil Impurity 17 (CAS 5440-00-6)
- Fluorouracil Impurity 27 (CAS 2566704-13-8)
- Fluorouracil Impurity 18 (CAS CATO-C4X-164918)
- Fluorouracil Impurity 23 (CAS CATO-C4X-164923)
Recommended Standards
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- (S)-tert-butyl (1-((5-bromopyridin-3-yl)oxy)-3-(1H-indol-3-yl)propan-2-yl)carbamate (CAS 882169-91-7)
- ((2R,3S,4R,5R)-5-(6-((S)-2-Aminopentanamido)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate (CAS 64145-30-8)
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- [3-(2,3-dihydro-1-benzofuran-5-yl)-4,5-dihydro-1,2-oxazol-5-yl]methanamine hydrochloride (CAS 1803561-63-8)
- 2-(Aminomethyl)-3-chloro-6-(difluoromethyl)pyridine-5-acetic acid (CAS 1806052-34-5)
- 10-Iodonaphtho[1,2-b]benzofuran (CAS 2271091-82-6)
- 5-(4-Methylpiperazin-1-yl)-1H-pyrazol-3-amine (CAS 537039-17-1)
- 2,2,4-Trimethyl-7-(trifluoromethyl)-1,2-dihydroquinoline (CAS 1242835-50-2)
- 4-Cyclopropoxy-5-methyl-2-(methylthio)pyridine (CAS 1243411-76-8)
- N-(6-Amino-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-3,5-di-tert-butyl-4-hydroxybenzamide (CAS 595558-79-5)
- N-(3-Amino-4-chlorophenyl)-3,4,5-trimethoxybenzamide (CAS 926194-71-0)
- Characteristic MSH-Tetrapeptide (CAS 4289-02-5)
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