Tamsulosin EP Impurity F CAS 6781-17-5
| CAS No. | 6781-17-5 |
| Molecular Formula | C10H15NO2 |
| Molecular Weight | 181.23 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Tamsulosin EP Impurity F (C10H15NO2) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Tamsulosin EP Impurity F (CAS 6781-17-5) is a certified pharmaceutical impurity reference standard with the molecular formula C10H15NO2 and a molecular weight of 181.23 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H15NO2 |
| Molecular Weight | 181.23 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Nitrogen Atoms | 1 |
Related Tamsulosin Standards
- Tamsulosin Impurity 12 (CAS CATO-C4X-118712)
- Tamsulosin Impurity 11 (CAS 3250-73-5)
- Tamsulosin Impurity 15 (CAS 3251-30-7)
- Tamsulosin Impurity 30 (CAS 589-10-6)
- Tamsulosin EP Impurity E (CAS 105764-07-6)
- Tamsulosin Impurity 28 (CAS 1495375-67-1)
- Tamsulosin Impurity 15 (CAS 92119-04-5)
- Tamsulosin Impurity 42 (CAS 94-71-3)
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- Paliperidone Impurity 156 (CAS 3109322-10-0)
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