Ketoconazole EP Impurity D(and enantiomer) CAS 67914-61-8
| CAS No. | 67914-61-8 |
| Molecular Formula | 2*C24H26Cl2N4O3 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C24H26Cl2N4O3, Ketoconazole EP Impurity D(and enantiomer) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 489.40 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Ketoconazole EP Impurity D(and enantiomer) (CAS 67914-61-8) is a certified pharmaceutical impurity reference standard with the molecular formula C24H26Cl2N4O3 and a molecular weight of 489.40 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Ketoconazole EP Impurity D(and enantiomer) meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | 2*C24H26Cl2N4O3 |
| Molecular Weight | 489.40 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1976 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Ketoconazole Standards
- Ketoconazole-d8 (CAS 1217706-96-1)
- Ketoconazole Impurity 21 (CAS 129643-72-7)
- Ketoconazole Impurity 18 (CAS 13256-06-9)
- Ketoconazole EP Impurity E (CAS 134071-44-6)
- Ketoconazole N-Oxide (CAS 1392277-16-5)
- (+)-Ketoconazole (CAS 142128-59-4)
- Ketoconazole Impurity N15 (CAS 170210-42-1)
- Ketoconazole Impurity 14 (CAS 170210-49-8)
Recommended Standards
- Ethinylestradiol EP Impurity H (CAS 1350468-76-6)
- Acalabrutinib Impurity 19 (CAS CATO-C4X-305519)
- Oryzanol Impurity 8 (CAS 20972-08-1)
- 2-Bromo-4-fluorobenzyl chloride (CAS 887140-03-6)
- (R)-1-(3-fluoro-4-methylphenyl)but-3-en-1-amine (CAS 1270086-88-8)
- 2-Aminopyrimidine-4,5,6(1H)-trione (CAS 52407-70-2)
- 2-Bromo-3-fluoro-6-methoxybenzoic acid (CAS 1781708-32-4)
- 1-(3,4-Dimethoxyphenyl)cyclohexane-1-carbonitrile (CAS 54802-32-3)
- 4-{[1,2,4]triazolo[4,3-a]pyrimidin-3-ylmethyl}aniline (CAS 1156664-91-3)
- Liraglutide Impurity 28 (CAS CATO-C4X-199228)
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