Ketoconazole Impurity 21 CAS 129643-72-7
| CAS No. | 129643-72-7 |
| Molecular Formula | C14H10Cl2O2 |
| Molecular Weight | 281.13 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Ketoconazole Impurity 21 (CAS 129643-72-7) is a certified pharmaceutical impurity reference standard with the molecular formula C14H10Cl2O2 and a molecular weight of 281.13 g/mol.
Structurally, Ketoconazole Impurity 21 (C14H10Cl2O2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, a polycyclic aromatic system. The molecule exhibits a degree of unsaturation (DBE) of 9.0, corresponding to approximately 9 ring(s) or double-bond equivalent(s). With a molecular weight of 281.13 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
CATO manufactures Ketoconazole Impurity 21 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C14H10Cl2O2 |
| Molecular Weight | 281.13 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1994 |
| Halogen Content | Cl-containing |
Related Ketoconazole Standards
- Ketoconazole Impurity 23 (CAS 29098-85-9)
- Ketoconazole Impurity 24 (CAS CATO-C4X-147224)
- Ketoconazole Impurity 7 (CAS 172032-21-2)
- Ketoconazole Impurity 22 (CAS CATO-C4X-147222)
- Ketoconazole Impurity 25 (CAS CATO-C4X-147225)
- Ketoconazole Impurity 19 (CAS CATO-C4X-147219)
- Ketoconazole Impurity 10 (CAS 61441-65-4)
- Ketoconazole Impurity 11 (CAS 84682-23-5)
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Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com