Hydroxyzine CAS 68-88-2
| CAS No. | 68-88-2 |
| Molecular Formula | C21H27ClN2O2 |
| Molecular Weight | 374.90 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Hydroxyzine is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Hydroxyzine (CAS 68-88-2), molecular formula C21H27ClN2O2 and molecular weight 374.90 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of Hydroxyzine (C21H27ClN2O2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), Hydroxyzine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H27ClN2O2 |
| Molecular Weight | 374.90 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Hydroxyzine Standards
- Hydroxyzine-d8DISCONTINUED (CAS 1189480-47-4)
- Hydroxyzine Impurity 2 (CAS CATO-C4X-16602)
- Hydroxyzine Impurity 5 (CAS 2469273-48-9)
- Hydroxyzine Impurity B Hydrochloride salt (CAS 1263283-80-2)
- Hydroxyzine Impurity 4 (CAS CATO-C4X-16604)
- Hydroxyzine Impurity 1 (CAS 628-89-7)
- Hydroxyzine Pamoate (CAS 10246-75-0)
- Hydroxyzine Impurity 9 (CAS 1031-92-1)
Recommended Standards
- Cyproterone (CAS 2098-66-0)
- 2-{[(4-chlorophenyl)methyl]sulfanyl}-5-methoxy-4-(phenylsulfanyl)pyrimidine (CAS 338423-06-6)
- Mometasone Furoate Impurity 24 (CAS CATO-C4X-170424)
- 3-({[(4-chlorophenyl)methyl]sulfanyl}methyl)-2H,3H,5H-[1,3]thiazolo[2,3-b]quinazolin-5-one (CAS 477860-28-9)
- (2-Ethoxy-1-iodo-2-oxoethyl)triphenylphosphonium iodide (CAS 111598-99-3)
- 2-(3-(Hydroxymethyl)pyrrolidin-1-yl)-N-propylacetamide (CAS 1251079-14-7)
- 1-(1-Bromobutan-2-yl)-4-fluorobenzene (CAS 7054-62-8)
- sodium 3-(pivaloyloxy)benzenesulfonate (CAS CATO-C3D-262870)
- N'-Hydroxy-2-[(4-methylphenyl)sulfonyl]-ethanimidamide (CAS 72660-98-1)
- n-(4-Ethyl-3-nitrophenyl)pivalamide (CAS 1090546-36-3)
- DBFphos (CAS 133850-81-4)
- 4,5-Dimethoxy-2-nitro-DL-phenylalanine (CAS 160342-61-0)
- 3-Chloro-5-mercaptobenzonitrile (CAS 895572-41-5)
- Semaglutide Impurity 130 (CAS 1188328-40-6)
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