Beclometasone Impurity 44 CAS 18769-20-5
| CAS No. | 18769-20-5 |
| Molecular Formula | C24H33ClO6 |
| Molecular Weight | 452.97 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Beclometasone Impurity 44 is closely related to a flavonoid core, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Beclometasone Impurity 44 (CAS 18769-20-5), a pharmacopoeial impurity reference standard (molecular formula C24H33ClO6, MW 452.97 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Beclometasone Impurity 44 (C24H33ClO6) contains a flavonoid core, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 8.0, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 452.97 g/mol, it falls into the moderately-high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C24H33ClO6 |
| Molecular Weight | 452.97 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1962 |
| Halogen Content | Cl-containing |
Related Beclometasone Standards
- Beclometasone dipropionate EP Impurity A (CAS 69224-79-9)
- Beclometasone dipropionate EP Impurity H (CAS 5534-18-9)
- Beclometasone Impurity 27 (CAS CATO-C4X-147427)
- Beclometasone Impurity 48 (CAS CATO-C4X-147448)
- Beclometasone Dipropionate Monohydrate EP Impurity I (CAS 52092-12-3)
- Beclometasone Impurity 38 (CAS CATO-C4X-147438)
- Beclometasone Impurity 53 (CAS CATO-C4X-147453)
- Beclometasone Dipropionate Monohydrate EP Impurity Q (CAS CATO-C4X-147417)
Recommended Standards
- 9,10-Bis(4-ethoxyphenyl)-2-chloroanthracene (CAS 135965-21-8)
- 1-{[3,5-Bis(trifluoromethyl)phenyl]methyl}-3,5-dibromo-1h-1,2,4-triazole (CAS 1240568-76-6)
- 7-(2-Chlorophenyl)-2-(4-(2-methoxyphenyl)piperazin-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one (CAS 1242932-94-0)
- 2,5-Bis(2,3,5-trichlorophenyl)pyridin-4-amine (CAS 1361585-50-3)
- Ceritinib Impurity 18 (CAS CATO-C4X-1048918)
- Mavacamten Intermediates Impurity 1 (CAS 887581-47-7)
- Resmetirom Impurity 99 (CAS CATO-C4X-291299)
- 2-Fluoro-5-(thiophen-2-yl)pyridine (CAS 1132832-80-4)
- Benzoyl-DL-leucine (CAS 17966-67-5)
- 1-(2,4-Dichlorobenzyl)-3-(4-fluorobenzyl)imidazolidine-2,4,5-trione (CAS 341966-52-7)
- 2-Benzyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-azaspiro[3.3]heptane (CAS 2706615-30-5)
- 3-((2,2-Dimethylcyclopropyl)amino)pyridazine-4-carboxylic acid (CAS 1539745-10-2)
- 1-(2-Hydroxy-5-methylfuran-3-yl)ethanone (CAS 318511-77-2)
- Semaglutide impurity 249 (CAS CATO-C4X-2226249)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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