Beclometasone dipropionate EP Impurity H CAS 5534-18-9
| CAS No. | 5534-18-9 |
| Molecular Formula | C25H33ClO6 |
| Molecular Weight | 464.98 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Beclometasone dipropionate EP Impurity H (CAS 5534-18-9) is a certified pharmaceutical impurity reference standard with the molecular formula C25H33ClO6 and a molecular weight of 464.98 g/mol.
Based on its molecular formula C25H33ClO6, Beclometasone dipropionate EP Impurity H contains a flavonoid core, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 464.98 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Beclometasone dipropionate EP Impurity H meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C25H33ClO6 |
| Molecular Weight | 464.98 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >90% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Cl-containing |
Related Beclometasone Standards
- Beclometasone dipropionate EP Impurity A (CAS 69224-79-9)
- Beclometasone Impurity 27 (CAS CATO-C4X-147427)
- Beclometasone Impurity 48 (CAS CATO-C4X-147448)
- Beclometasone Dipropionate Monohydrate EP Impurity I (CAS 52092-12-3)
- Beclometasone Impurity 38 (CAS CATO-C4X-147438)
- Beclometasone Impurity 53 (CAS CATO-C4X-147453)
- Beclometasone Dipropionate Monohydrate EP Impurity Q (CAS CATO-C4X-147417)
- Beclometasone Impurity 44 (CAS 18769-20-5)
Recommended Standards
- N-(4-Chlorophenethyl)-3-((4-methoxy-N-methylphenyl)sulfonamido)thiophene-2-carboxamide (CAS 1116017-47-0)
- Alclometasone Dipropionate Impurity 4 (CAS 76576-24-4)
- 1-(4-Chlorophenyl)-4-{[2-(3,5-dimethyl-1H-pyrazole-1-carbonyl)thiophen-3-yl]sulfonyl}piperazine (CAS 1171812-17-1)
- 9,9'-(5-Chloro-1,3-phenylene)diphenanthrene (CAS 1369431-34-4)
- Nafamostat impurity 112 HCl (CAS CATO-C4X-1332112)
- Ketoprofen Impurity 102 (CAS CATO-C4X-1471102)
- Levofolinate Impurity 13 Calcium Salt (CAS CATO-C4X-133513)
- 3-(2,6-Difluorophenyl)-1-(furan-2-ylmethyl)-1-(thiophen-3-ylmethyl)urea (CAS 1219903-97-5)
- 1-(1H-indol-7-yl)propan-1-one (CAS 2306278-36-2)
- 4-(Bromomethyl)-3-(difluoromethyl)-6-hydroxypicolinaldehyde (CAS 1805088-69-0)
- Kirromycin (CAS 50935-71-2)
- 2-Chloro-N-(4-isopropoxyphenyl)acetamide (CAS 100129-54-2)
- Glutamic acid impurity 6 (CAS 1308957-12-1)
- Neuropeptide S (human) (CAS 412938-67-1)
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