Norfloxacin EP Impurity G CAS 70459-04-0
| CAS No. | 70459-04-0 |
| Molecular Formula | C17H18FN3O4 |
| Molecular Weight | 347.34 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Norfloxacin EP Impurity G.
Norfloxacin EP Impurity G (CAS 70459-04-0) is a certified pharmaceutical impurity reference standard with the molecular formula C17H18FN3O4 and a molecular weight of 347.34 g/mol.
Based on its molecular formula C17H18FN3O4, Norfloxacin EP Impurity G contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 347.34 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Norfloxacin EP Impurity G meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C17H18FN3O4 |
| Molecular Weight | 347.34 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1977 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Norfloxacin Standards
- Norfloxacin Impurity C25 (CAS 74011-47-5)
- Norfloxacin EP Impurity E (CAS 75001-85-3)
- Norfloxacin EP Impurity F (CAS 67681-84-9)
- Norfloxacin Impurity 65 (CAS CATO-C4X-146865)
- Norfloxacin Piperazinyl-1-Oxide (CAS 1796931-70-8)
- Norfloxacin Impurity 22 (CAS 109142-49-6)
- Norfloxacin Impurity 50 (CAS CATO-C4X-146850)
- Norfloxacin Impurity 31 (CAS CATO-C4X-146831)
Recommended Standards
- Levofloxacin EP Impurity B (CAS 117707-40-1)
- 1008867-63-7 1X-0235 3-[(4E)-4-[(2H-1,3-benzodioxol-5-yl)methylidene]-5-oxo-4,5-dihydro-1H-imidazol-2-yl]-1,3-thiazolidine-4-carboxylic acid (CAS 1008867-63-7)
- Levofloxacin Impurity 22 (CAS 82419-46-3)
- tert-Butyl 4-((((trifluoromethyl)sulfonyl)oxy)methyl)piperidine-1-carboxylate (CAS 1420797-21-2)
- Sevoflurane Impurity 14 (CAS 462-51-1)
- Nisoldipine Impurity 1 (CAS 2226462-71-9)
- Darolutamide Impurity 44 (CAS CATO-C4X-310644)
- 1-(4-(3-Benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)piperazin-1-yl)ethan-1-one (CAS 842104-34-1)
- (4,5-Dihydroisoxazol-3-yl)(phenyl)methanamine (CAS 1258650-09-7)
- 2-(1-(2-Fluorobenzyl)piperidin-4-yl)-1H-benzo[d]imidazole (CAS 887217-21-2)
- 2-Bromo-1,1,1-trifluoro-dodecane (CAS 1349719-10-3)
- (1-Amino-4-methylpentan-2-yl)(1-phenylethyl)amine (CAS 1311314-37-0)
- n-[1-(1,5-dimethyl-1h-pyrazol-4-yl)ethylidene]hydroxylamine (CAS 1019067-48-1)
- Neuropeptide Y (18-36) (CAS 114495-97-5)
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