Methotrexate Impurity N2 CAS 708-74-7
| CAS No. | 708-74-7 |
| Molecular Formula | C7H8N6 |
| Molecular Weight | 176.18 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Methotrexate Impurity N2 (CAS 708-74-7, C7H8N6) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Methotrexate Impurity N2 (C7H8N6) contains a nitrile group, an aromatic ring system. Its physicochemical properties are representative of its class; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
CATO manufactures Methotrexate Impurity N2 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C7H8N6 |
| Molecular Weight | 176.18 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 6 |
Related Methotrexate Standards
- Methotrexate impurity N1 (CAS 4215-07-0)
- Methotrexate Impurity 62 (CAS 942840-87-1)
- Methotrexate Impurity N6 (CAS 4261-17-0)
- Methotrexate EP Impurity A (CAS 945-24-4)
- Methotrexate Impurity 30 (CAS 881-33-4)
- Methotrexate Impurity 25 (CAS CATO-C4X-115425)
- Methotrexate Impurity 26 (CAS CATO-C4X-115426)
- Methotrexate impurity N4 (CAS 54643-27-5)
Recommended Standards
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- 2-Amino-1H-benzo[d]imidazole-4-carboxamide (CAS 636574-52-2)
- Moxifloxacin Impurity 83 (CAS 1829588-19-3)
- Ketoprofen Impurity 35 (CAS 108315-48-6)
- Ammoxetine Impurity 23 (CAS CATO-C4X-224423)
- Tert-butyl 3-(1-aminocyclopropyl)-3-fluoroazetidine-1-carboxylate (CAS 1780614-97-2)
- cis-Bicyclo[4.3.0]nonane (CAS 4551-51-3)
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- (Cys2)-Neuropeptide Y-8-aminooctanoyl-(D-Cys27)-Neuropeptide Y (25-32) (H-3298.0500) (CAS 128806-04-2)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com