Methotrexate Impurity N6 CAS 4261-17-0
| CAS No. | 4261-17-0 |
| Molecular Formula | C7H6N6O |
| Molecular Weight | 190.16 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Methotrexate Impurity N6 (C7H6N6O) is characterized by an amide group, a hydroxyl group, an ether linkage, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
CATO supplies Methotrexate Impurity N6 (CAS 4261-17-0), a pharmacopoeial impurity reference standard (molecular formula C7H6N6O, MW 190.16 g/mol) used for the identification and quantification of trace impurities in APIs.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Methotrexate Impurity N6 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C7H6N6O |
| Molecular Weight | 190.16 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Nitrogen Atoms | 6 |
Related Methotrexate Standards
- Methotrexate EP Impurity A (CAS 945-24-4)
- Methotrexate Impurity 30 (CAS 881-33-4)
- Methotrexate Impurity N2 (CAS 708-74-7)
- Methotrexate impurity N1 (CAS 4215-07-0)
- Methotrexate impurity N4 (CAS 54643-27-5)
- Methotrexate Impurity N5 (CAS 56364-06-8)
- Methotrexate Impurity 62 (CAS 942840-87-1)
- Methotrexate Impurity 60 (CAS CATO-C4X-115460)
Recommended Standards
- Imiquimod Impurity 9 (CAS 23432-46-4)
- N-(2-((2-hydrazinyl-2-oxoethyl)amino)acetyl)nitrous Hydrazide (CAS 5438-82-4)
- Bromocycloheptane-d (CAS 35558-50-0)
- N-Cyano-3-nitrobenzenecarboximidamide (CAS 23275-42-5)
- Rosuvastatin Impurity 107 (CAS 122549-26-2)
- Spironolactone Impurity 20 (CAS CATO-C4X-134520)
- Fosaprepitant Impurity 46 (CAS CATO-C4X-116846)
- 5,7-Dichloro-2-methylpyrido[3,4-b]pyrazine (CAS 1415793-75-7)
- 2-(2-methyl-1,3-thiazol-4-yl)ethan-1-amine dihydrobromide (CAS 1423031-19-9)
- 2-(Difluoromethyl)-3-nitro-5-(trifluoromethoxy)pyridine-6-acetonitrile (CAS 1361737-10-1)
- Methyl 3,5-dibromo-2,4-dihydroxy-6-methylbenzoate (CAS 715-33-3)
- Salicylic Acid Impurity 26 (CAS 2100-31-4)
- 2-Oxo-1,2,3,4-tetrahydroquinoline-7-sulfonyl chloride (CAS 947499-04-9)
- GnRH Associated Peptide (GAP) (1-13), human (CAS 100111-07-7)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com