Celecoxib Impurity 49 CAS 720-94-5
| CAS No. | 720-94-5 |
| Molecular Formula | C11H9F3O2 |
| Molecular Weight | 230.18 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO manufactures Celecoxib Impurity 49 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
As a process- or degradation-related impurity, Celecoxib Impurity 49 (CAS 720-94-5, C11H9F3O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Celecoxib Impurity 49 (C11H9F3O2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C11H9F3O2 |
| Molecular Weight | 230.18 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
Related Celecoxib Standards
- Celecoxib Impurity 22 (CAS 163266-02-2)
- Celecoxib Impurity 25 (CAS CATO-C4X-104325)
- Celecoxib Impurity 67 (CAS 910303-54-7)
- Celecoxib Impurity 57 (CAS CATO-C4X-104357)
- Celecoxib Impurity 59 (CAS CATO-C4X-104359)
- Celecoxib Impurity 11 (CAS 219986-64-8)
- Celecoxib Impurity 54 (CAS 948293-46-7)
- Celecoxib Impurity 1 (CAS 54779-81-6)
Recommended Standards
- Cinacalcet Impurity 96 (CAS CATO-C4X-105996)
- (4-ethenylphenyl)methyl 2,2,2-tris(fluoranyl)ethanoate 2,2,2-trifluoroacetic acid (4-ethenylphenyl)methyl ester 229956-99-4 A816465 (CAS 229956-99-4)
- Moxifloxacin Impurity 55 (CAS 53764-99-1)
- Methyl 4-[1-(trifluoromethyl)vinyl]benzoate (CAS 357274-86-3)
- Donepezil EP impurity A (CAS 120014-30-4)
- Tryptophan Impurity 50 HCl (CAS CATO-C4X-137350)
- Cilastatin Impurity 15 Sodium salt (CAS CATO-C4X-196015)
- 6-Ethyl-2-hydroxy-5-methylnicotinic acid (CAS 889939-68-8)
- Dronedarone Impurity 92 (CAS 141626-35-9)
- Pyrrolidine-2-carbonitrile 2,2,2-trifluoroacetate (CAS 1523606-34-9)
- 3-Chloro-N-(3,5-dimethylphenyl)-2,2-dimethylpropanamide (CAS 341965-95-5)
- 3-Bromo-5-(methylsulfinyl)pyridine (CAS 1193245-15-6)
- 3,4-Difluoro-L-phenylalanine (CAS 31105-90-5)
- Des-Pro31-Tirzepatide (CAS CATO-CPTD788943)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com