Letrozole Impurity 15 CAS 74231-65-5
| CAS No. | 74231-65-5 |
| Molecular Formula | C8H5Cl2N |
| Molecular Weight | 186.04 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Letrozole Impurity 15 is closely related to a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Letrozole Impurity 15 (CAS 74231-65-5) is a certified pharmaceutical impurity reference standard with the molecular formula C8H5Cl2N and a molecular weight of 186.04 g/mol.
Structurally, Letrozole Impurity 15 (C8H5Cl2N) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 6.0, corresponding to approximately 6 ring(s) or double-bond equivalent(s). With a molecular weight of 186.04 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Letrozole Impurity 15 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C8H5Cl2N |
| Molecular Weight | 186.04 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1978 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Letrozole Standards
- Letrozole Impurity 17 (CAS 112809-27-5)
- Letrozole Impurity 22 (CAS 876728-37-9)
- Letrozole Impurity 23 (CAS 876316-41-5)
- Letrozole Impurity 4 (CAS 112809-25-3)
- Letrozole Impurity 28 (CAS 46209-39-6)
- Letrozole Impurity 39 (CAS 28188-41-2)
- Letrozole Impurity 24 (CAS CATO-C4X-182924)
- Letrozole Impurity 33 (CAS 1461654-89-6)
Recommended Standards
- 2,4-Dichloro-6-methoxy-1,3,5-triazine 3638-04-8 Methacryloxyethyl sulfobetaine N-(3-Sulfopropyl)-N-(methacryloxyethyl)-N,N-dimethylammonium (CAS 3638-04-8)
- 4-Bromo-3-ethylpyridine (CAS 10168-60-2)
- 5,7-Dichloroindole (CAS 4792-72-7)
- 3-Bromobenzylamine (CAS 10269-01-9)
- Esomeprazole Impurity 116 (CAS 109371-19-9)
- Acetylcysteine Impurity 17 TFA salt (CAS CATO-C4X-153255)
- Relebactam Impurity 74 (CAS CATO-C4X-214474)
- Tasimelteon Impurity 1 (CAS 209255-72-1)
- (S)-tert-Butyl (1-(2-hydroxyethyl)pyrrolidin-3-yl)(isopropyl)carbamate (CAS 1354007-85-4)
- Methyl 2-cyano-5-methoxybenzoate (CAS 127510-95-6)
- 7-(2-Fluorobenzyl)-1,3-dimethyl-8-(piperidin-1-yl)-3,7-dihydro-1H-purine-2,6-dione (CAS 332116-01-5)
- Pyrene-1,3,6,8-tetracarbonitrile (CAS 28496-11-9)
- (2S,5R)-5-[4-[(2-FLUOROPHENYL)METHOXY]PHENYL]-2-PYRROLIDINECARBOXAMIDE HCL (CAS 1044910-30-6)
- Semaglutide Impurity 177 (CAS CATO-C4X-2226177)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com