Letrozole Impurity 23 CAS 876316-41-5

Description

The occurrence of Letrozole Impurity 23 is closely related to a nitrogen-containing heterocyclic scaffold, a nitrile group in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.

Letrozole Impurity 23 (CAS 876316-41-5) is a certified pharmaceutical impurity reference standard with the molecular formula C10H8N4 and a molecular weight of 184.20 g/mol.

Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, Letrozole Impurity 23 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 184.20 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).

Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.

As a certified reference material (CRM), Letrozole Impurity 23 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

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