Letrozole Impurity 4 CAS 112809-25-3

Purity >90%In StockPharmacopoeial Impurity Standards
CAS No.112809-25-3
Molecular FormulaC10H8N4
Molecular Weight184.20 g/mol
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Letrozole Impurity 4 CAS 112809-25-3 chemical structure

Description

The occurrence of Letrozole Impurity 4 is closely related to a nitrogen-containing heterocyclic scaffold, a nitrile group in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.

CATO supplies Letrozole Impurity 4 (CAS 112809-25-3), a pharmacopoeial impurity reference standard (molecular formula C10H8N4, MW 184.20 g/mol) used for the identification and quantification of trace impurities in APIs.

Letrozole Impurity 4 (C10H8N4) contains a nitrogen-containing heterocyclic scaffold, a nitrile group. Its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.

Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

Molecular FormulaC10H8N4
Molecular Weight184.20 g/mol
AppearancePale yellow to yellow crystalline powder. (faint amine-like odor)
Purity>90%
StorageStore at 2-8°C, protect from light
Solubility (reference)Soluble in DMSO, DMF, methanol
StabilityLight-sensitive; avoid direct strong light
Degree of Unsaturation (DBE)9.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1989
Nitrogen Atoms4

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