Posaconazole Impurity 103 CAS 74852-62-3

Purity >95%In StockPharmacopoeial Impurity Standards
CAS No.74852-62-3
Molecular FormulaC17H21N3O
Molecular Weight283.37 g/mol
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Posaconazole Impurity 103 CAS 74852-62-3 chemical structure

Description

CATO supplies Posaconazole Impurity 103 (CAS 74852-62-3), a pharmacopoeial impurity reference standard (molecular formula C17H21N3O, MW 283.37 g/mol) used for the identification and quantification of trace impurities in APIs.

The molecular framework of Posaconazole Impurity 103 (C17H21N3O) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.

This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

Molecular FormulaC17H21N3O
Molecular Weight283.37 g/mol
AppearancePale yellow to yellow crystalline powder
Purity>95%
StorageStore at 2-8°C, protect from light
Solubility (reference)Soluble in DMSO, DMF, methanol
StabilityLight-sensitive; avoid direct strong light
Degree of Unsaturation (DBE)9.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1978
Nitrogen Atoms3

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