Dexamethasone Impurity 33 CAS 75262-69-0
| CAS No. | 75262-69-0 |
| Molecular Formula | C21H27FO4 |
| Molecular Weight | 362.44 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Dexamethasone Impurity 33 (CAS 75262-69-0) is a certified pharmaceutical impurity reference standard with the molecular formula C21H27FO4 and a molecular weight of 362.44 g/mol.
Dexamethasone Impurity 33 (C21H27FO4) contains a flavonoid core, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Dexamethasone Impurity 33 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H27FO4 |
| Molecular Weight | 362.44 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1978 |
| Halogen Content | F-containing |
Related Dexamethasone Standards
- Dexamethasone impurity 89 (CAS CATO-C4X-116589)
- Dexamethasone Impurity 85 (CAS CATO-C4X-116585)
- Dexamethasone Impurity 94 (CAS 59861-00-6)
- Dexamethasone EP Impurity E (CAS 13209-41-1)
- Dexamethasone Impurity 58 (CAS CATO-C4X-116558)
- Dexamethasone EP Impurity K (CAS 1809224-82-5)
- Dexamethasone EP Impurity J (CAS 2036-77-3)
- Dexamethasone EP Impurity D (CAS 24916-90-3)
Recommended Standards
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