Losartan Impurity 46 CAS 757149-84-1
| CAS No. | 757149-84-1 |
| Molecular Formula | C22H21Cl2N3 |
| Molecular Weight | 398.33 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Losartan Impurity 46 is closely related to a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Losartan Impurity 46 (CAS 757149-84-1) is a certified pharmaceutical impurity reference standard with the molecular formula C22H21Cl2N3 and a molecular weight of 398.33 g/mol.
Losartan Impurity 46 (C22H21Cl2N3) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Losartan Impurity 46 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H21Cl2N3 |
| Molecular Weight | 398.33 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Losartan Standards
- Losartan Impurity 33 (CAS 114798-27-5)
- Losartan Impurity G (CAS 165276-38-0)
- Losartan Impurity 30 (CAS 2755908-48-4)
- Losartan Impurity N2 (CAS 1351793-76-4)
- Losartan Impurity 37 (CAS CATO-C4X-168337)
- Losartan Impurity 15 (CAS 114772-55-3)
- Losartan Impurity 29 (CAS 2204369-11-7)
- Losartan Impurity 51 (CAS CATO-C4X-168351)
Recommended Standards
- N-benzyl-5-oxo-2-(trifluoromethyl)-5H-chromeno[2,3-b]pyridine-3-carboxamide (CAS 339020-73-4)
- Etofenamate Impurity 2 (CAS CATO-C4X-26032)
- Ethyl 2-(4-{[2-nitro-4-(trifluoromethyl)phenyl]amino}phenoxy)propanoate (CAS 73553-87-4)
- Resmetirom Impurity 27 (CAS CATO-C4X-291227)
- Sildenafil Impurity 263 (CAS CATO-C4X-1128263)
- Ramipril EP Impurity C Hydrochloride (CAS 885516-61-0)
- Aprepitant Impurity 48 (CAS 380499-07-0)
- 2-butoxypropanoic acid (CAS 14620-87-2)
- Metamizole free (CAS 50567-35-6)
- 2-(4-Toluidino)isonicotinic acid (CAS 1019452-51-7)
- 4,5,6,7-Tetrahydro-3H-imidazo[4,5-c]pyridine-6-carboxylic acid dihydrochloride (CAS 1218463-60-5)
- 3-Chloro-N-{[3-(2-methylpyrimidin-4-yl)-4,5-dihydro-1,2-oxazol-5-yl]methyl}-5-(trifluoromethyl)pyridin-2-amine (CAS 344277-27-6)
- 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide (CAS 188665-75-0)
- D-[Arg]30-Semaglutide (CAS CATO-C4X-222653)
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