Aprepitant Impurity 48 CAS 380499-07-0
| CAS No. | 380499-07-0 |
| Molecular Formula | C20H16F7NO2 |
| Molecular Weight | 435.34 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Aprepitant Impurity 48 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies Aprepitant Impurity 48 (CAS 380499-07-0), a pharmacopoeial impurity reference standard (molecular formula C20H16F7NO2, MW 435.34 g/mol) used for the identification and quantification of trace impurities in APIs.
Aprepitant Impurity 48 (C20H16F7NO2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C20H16F7NO2 |
| Molecular Weight | 435.34 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Aprepitant Standards
- Aprepitant Impurity 22 (CAS 934540-48-4)
- Aprepitant impurity 01 (CAS 171338-27-5)
- Aprepitant Impurity 41 (CAS CATO-C4X-114141)
- Aprepitant Impurity 43 (CAS CATO-C4X-114143)
- Aprepitant Impurity 30 (CAS 172678-47-6)
- Aprepitant Impurity 23 (CAS 287930-75-0)
- Aprepitant Impurity 24 (CAS 327623-36-9)
- Aprepitant Impurity 25 (CAS CATO-C4X-114125)
Recommended Standards
- tert-Butyldimethyl[(tributylstannyl)methoxy]silane (CAS 123061-64-3)
- 5-((4-Bromophenyl)thio)-1,3-diphenyl-1H-pyrazole-4-carbaldehyde (CAS 956183-52-1)
- Benzyl-PEG6-bromide (CAS 1449202-44-1)
- 2-[4-(4-Bromobenzenesulfonyl)piperazin-1-yl]-4,6-dimethylpyridine-3-carbonitrile (CAS 478081-74-2)
- Brexpiprazole Impurity 138 (CAS CATO-C4X-1131138)
- Moxifloxacin Impurity 193 (CAS CATO-C4X-1074193)
- Tribenoside Impurity 1 (CAS CATO-C4X-29261)
- 4,6-Dibromonicotinaldehyde (CAS 1211585-10-2)
- N-Boc-3-hydroxy-1,2,3,6-tetrahydropyridine (CAS 224779-27-5)
- Dopamine Impurity 87 HCI (CAS 88408-41-7；102851-70-7（free base）)
- 1-[3,5-Bis(trifluoromethyl)phenyl]cyclobutanamine (CAS 1314714-46-9)
- Ethyl 1-(2-fluorophenyl)-4-hydroxy-1H-pyrazole-3-carboxylate (CAS 379238-80-9)
- (1-Cyclopropyl-1h-benzo[d]imidazol-5-yl)methanamine (CAS 1266789-96-1)
- Semaglutide impurity 199 (CAS CATO-C4X-2226199)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com