Nintedanib Impurity 90 CAS CATO-C4X-181490
| CAS No. | CATO-C4X-181490 |
| Molecular Formula | C9H9Cl3O2 |
| Molecular Weight | 255.53 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Nintedanib Impurity 90 (CAS CATO-C4X-181490, C9H9Cl3O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Nintedanib Impurity 90 (C9H9Cl3O2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 4.0, corresponding to approximately 4 ring(s) or double-bond equivalent(s). With a molecular weight of 255.53 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
CATO manufactures Nintedanib Impurity 90 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C9H9Cl3O2 |
| Molecular Weight | 255.53 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
Related Nintedanib Standards
- Nintedanib Impurity 135 (CAS CATO-C4X-1814135)
- Nintedanib Impurity 137 (CAS CATO-C4X-1814137)
- Nintedanib Impurity 138 (CAS CATO-C4X-1814138)
- Nintedanib Impurity 139 (CAS CATO-C4X-1814139)
- Nintedanib Impurity 141 (CAS CATO-C4X-1814141)
- Nintedanib Impurity 142 (CAS CATO-C4X-1814142)
- Nintedanib Impurity 92 (CAS CATO-C4X-181492)
- Nintedanib Impurity 31 (CAS 2514952-69-1)
Recommended Standards
- 2,2,2-Trichloro-1-(4-methoxyphenyl)ethanol (CAS 14337-31-6)
- 1-Bromo-4-(chloromethyl)naphthalene (CAS 101828-11-9)
- 1-(4-(Aminomethyl)-1-methyl-1h-pyrrol-2-yl)-2,2,2-trichloroethan-1-one (CAS 1384430-78-7)
- 3-Chloro-2,4,5-trifluoro-6-nitrobenzoic acid (CAS 111230-48-9)
- Sarpogrelate Impurity 17 HCl (CAS 1659311-40-6(free base))
- Atorvastatin Impurity 130 (CAS 1193817-52-5)
- Deoxycholic acid Impurity 29 (CAS 61289-17-6)
- 4-Azetidin-3-yl-pyrimidin-2-ylaminetris(trifluoroacetic acid salt) (CAS 1361113-32-7)
- 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-amine (CAS 948593-70-2)
- N-(3-Methylisoxazol-5-yl)-2-((6-phenylpyrimidin-4-yl)thio)acetamide (CAS 1203372-33-1)
- 1,3,5,2,4,6-Trioxatriphosphorinane, 2,4,6-tributyl-, 2,4,6-trioxide(50% in EA) (CAS 163755-62-2)
- (E)-3-(furan-2-yl)-2-(4-phenylthiazol-2-yl)acrylonitrile (CAS 277308-31-3)
- Rel-(2R,3S)-3-methyltetrahydrofuran-2-carboxylic acid (CAS 617690-22-9)
- ((Cys31,Nva34)-Neuropeptide Y (27-36))2 (CAS 172997-92-1)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com