Olaparib Impurity 40 CAS CATO-C4X-113540
| CAS No. | CATO-C4X-113540 |
| Molecular Formula | C24H24ClFN4O3 |
| Molecular Weight | 470.92 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Olaparib Impurity 40 (CAS CATO-C4X-113540, C24H24ClFN4O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Olaparib Impurity 40 (C24H24ClFN4O3) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C24H24ClFN4O3 |
| Molecular Weight | 470.92 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
Related Olaparib Standards
- Olaparib Impurity 49 (CAS CATO-C4X-113549)
- Olaparib Impurity N12 (CAS 763114-04-1)
- Olaparib Impurity 28 (CAS 1187479-72-6)
- Olaparib Impurity 128 (CAS CATO-C4X-1135128)
- Olaparib Impurity 161 (CAS CATO-C4X-1135161)
- Olaparib Impurity 162 (CAS CATO-C4X-1135162)
- Olaparib Impurity 83 (CAS CATO-C4X-113583)
- Olaparib Impurity 84 (CAS CATO-C4X-113584)
Recommended Standards
- N-(7-Amino-4-chloro-1-(2,2-difluoroethyl)-1H-indazol-3-yl)-N-(4-methoxybenzyl)cyclopropanesulfonamide (CAS 2249975-84-4)
- Dacomitinib Impurity 47 (CAS CATO-C4X-208647)
- 2-(4-Benzoylphenyl)-N-[(1E)-[(4-chlorophenyl)amino]methylidene]-2-(4-fluorophenyl)acetamide (CAS 860609-46-7)
- ((3-(2-Chloroethyl)-2-oxido-1,3,2-oxazaphosphinan-2-yl)azanediyl)bis(propane-3,1-diyl) dimethanesulfonate (CAS 37752-32-2)
- Pimobendan EP Impurity B (CAS 74149-74-9)
- Des-SVEAK impurity (CAS CATO-CPTD789030)
- Octreotide Impurity 31 (CAS CATO-C4X-152031)
- 4-Cyclopropoxy-3-ethylpicolinaldehyde (CAS 1243394-51-5)
- Ethyl 2-(3-(2-chlorophenyl)-5-methylisoxazole-4-carboxamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (CAS 301680-88-6)
- Empagliflozin impurity 241 (CAS CATO-C4X-1065241)
- Rivaroxaban Impurity 209 (CAS CATO-C4X-1090209)
- 3-(2,4-Dichlorophenoxymethyl)-1h-1,2,4-triazole-5-carboxamide (CAS 400080-22-0)
- 2-((3,5-Dichlorobenzyl)amino)propan-1-ol (CAS 1179107-42-6)
- [5-31]-Semaglutide (CAS CATO-C4X-2226263)
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