Ataluren Impurity 6 CAS 775304-58-0
| CAS No. | 775304-58-0 |
| Molecular Formula | C15H9FN2O3 |
| Molecular Weight | 284.24 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Ataluren Impurity 6 (CAS 775304-58-0) is a certified pharmaceutical impurity reference standard with the molecular formula C15H9FN2O3 and a molecular weight of 284.24 g/mol.
Structurally, Ataluren Impurity 6 (C15H9FN2O3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 12.0, corresponding to approximately 12 ring(s) or double-bond equivalent(s). With a molecular weight of 284.24 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), Ataluren Impurity 6 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H9FN2O3 |
| Molecular Weight | 284.24 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Ataluren Standards
- Ataluren (CAS 775304-57-9)
- Ataluren Impurity N (CAS 775304-56-8)
- Ataluren Impurity 3 (CAS CATO-C4X-30063)
- Ataluren Impurity 10 (CAS CATO-C4X-300610)
- Ataluren Impurity 11 (CAS CATO-C4X-300611)
- Ataluren Impurity 14 (CAS CATO-C4X-300614)
- Ataluren Impurity 5 (CAS 775304-28-4)
- Ataluren Impurity 7 (CAS 775303-92-9)
Recommended Standards
- Olaparib Impurity 76 (CAS CATO-C4X-113576)
- 1-(5-Fluoro-2,4-Dinitrophenyl)-4-Methylpiperazine (CAS 928830-73-3)
- Olaparib Impurity 37 (CAS 1423030-11-8)
- (2R,3R,4S,5R)-5-(2,6-Diamino-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)tetrahydrofuran-3-ol (CAS 103884-97-5)
- Aztreonam Impurity 51 (CAS CATO-C4X-152251)
- Ibuprofen Impurity 64 (CAS CATO-C4X-108264)
- Salmeterol EP Impurity F (CAS 1391054-40-2)
- (1,3-Dimethyl-1H-pyrazol-5-yl)methanamine hydrochloride (CAS 1208077-49-9)
- 2-Chloro-4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine (CAS 2223052-31-9)
- Ethyl 4-([1,1'-biphenyl]-4-yl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate (CAS 1099644-42-4)
- tert-butyl 5-formyl-1-methyl-1H-pyrazole-4-carboxylate (CAS 1909316-95-5)
- 2-Hydroxy Trimipramine-d3 (CAS 1189647-53-7)
- 2-(2,2-dichloro-1-methylcyclopropyl)ethan-1-amine hydrochloride (CAS 1864061-31-3)
- Antifreeze Polypeptide 6 (winter flounder) trifluoroacetate salt (CAS 122604-16-4)
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